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Effectiveness of voriconazole and corneal cross-linking on Phialophora verrucosa keratitis: a case report

Overview of attention for article published in Journal of Medical Case Reports, August 2018
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Title
Effectiveness of voriconazole and corneal cross-linking on Phialophora verrucosa keratitis: a case report
Published in
Journal of Medical Case Reports, August 2018
DOI 10.1186/s13256-018-1765-1
Pubmed ID
Authors

Marisa Taechajongjintana, Ngamjit Kasetsuwan, Usanee Reinprayoon, Sirinuch Sawanwattanakul, Phattrawan Pisuchpen

Abstract

We report a rare case of Phialophora verrucosa fungal keratitis, which required various types of treatment according to the intractable natural history of the disease. A 51-year-old Thai man with poorly controlled diabetes received a bamboo branch injury and developed a perforated corneal lesion on his left eye. A pathological study from therapeutic penetrating keratoplasty showed fungal hyphae. This was later identified as Phialophora verrucosa by polymerase chain reaction. This organism was aggressive and recalcitrant because it relapsed with two corneal grafts and was resistant to amphotericin B, natamycin, and itraconazole. However, we found that the efficacy of voriconazole was promising for treating Phialophora verrucosa. We also used corneal cross-linking to establish corneal integrity after the infection was under control. Because of the chronic nature of Phialophora verrucosa, a patient's first visit may occur many years after trauma, and sometimes clinical presentation might not appear to indicate fungal infection. Therefore, a high index of suspicion is needed in this situation. Voriconazole showed good results in our case. Instead of using a more invasive keratoplasty, we used corneal cross-linking to strengthen the corneal biomechanics. To the best of our knowledge, this is the first case showing the benefit of corneal cross-linking to improve corneal biomechanics in resolved Phialophora verrucosa keratitis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 40%
Professor > Associate Professor 2 20%
Lecturer 1 10%
Student > Postgraduate 1 10%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 5 50%
Agricultural and Biological Sciences 1 10%
Veterinary Science and Veterinary Medicine 1 10%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2018.
All research outputs
#10,767,938
of 13,528,132 outputs
Outputs from Journal of Medical Case Reports
#1,288
of 2,325 outputs
Outputs of similar age
#199,407
of 265,925 outputs
Outputs of similar age from Journal of Medical Case Reports
#1
of 1 outputs
Altmetric has tracked 13,528,132 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,325 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them