Title |
Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes
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Published in |
BMC Medical Genomics, November 2011
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DOI | 10.1186/1755-8794-4-80 |
Pubmed ID | |
Authors |
Alejandra Rodriguez-Martinez, Emma-Leena Alarmo, Lilli Saarinen, Johanna Ketolainen, Kari Nousiainen, Sampsa Hautaniemi, Anne Kallioniemi |
Abstract |
Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily of growth factors. They are known for their roles in regulation of osteogenesis and developmental processes and, in recent years, evidence has accumulated of their crucial functions in tumor biology. BMP4 and BMP7, in particular, have been implicated in breast cancer. However, little is known about BMP target genes in the context of tumor. We explored the effects of BMP4 and BMP7 treatment on global gene transcription in seven breast cancer cell lines during a 6-point time series, using a whole-genome oligo microarray. Data analysis included hierarchical clustering of differentially expressed genes, gene ontology enrichment analyses and model based clustering of temporal data. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
France | 1 | 2% |
Singapore | 1 | 2% |
Unknown | 42 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 27% |
Researcher | 7 | 16% |
Student > Doctoral Student | 4 | 9% |
Professor > Associate Professor | 4 | 9% |
Student > Master | 4 | 9% |
Other | 8 | 18% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 42% |
Medicine and Dentistry | 8 | 18% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Computer Science | 2 | 4% |
Engineering | 2 | 4% |
Other | 0 | 0% |
Unknown | 8 | 18% |