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Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes

Overview of attention for article published in BMC Infectious Diseases, August 2018
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Title
Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes
Published in
BMC Infectious Diseases, August 2018
DOI 10.1186/s12879-018-3348-6
Pubmed ID
Authors

Jamile Leão Rêgo, Nadja de Lima Santana, Paulo Roberto Lima Machado, Marcelo Ribeiro-Alves, Thiago Gomes de Toledo-Pinto, Léa Cristina Castellucci, Milton Ozório Moraes

Abstract

The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of reactions, which is consistent with the exacerbated immune response exhibited by these patients. We used qPCR to screen a panel of 90 genes related to the immune response in leprosy in RNA-derived peripheral leukocytes of patients with (N = 94) and without leprosy reactions (N = 57) in order to define expression signatures correlated to RR or ENL. Our results show that there is a marked signature for RR in the blood, comprising genes mostly related to the innate immune responses, including type I IFN components, autophagy, parkins and Toll like receptors. On the other hand, only Parkin was differentially expressed in the ENL group. The data put together corroborates previous work that brings evidence that an acute uncontrolled exacerbated immune response designed to contain the spread of M. leprae antigens might be cause of RR pathogenesis. Identifying a blood profile useful to predict leprosy reactions prior to its development might help to reduce the morbidity associated to this disabling disease.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 14%
Student > Master 4 11%
Researcher 4 11%
Student > Doctoral Student 2 5%
Lecturer 2 5%
Other 5 14%
Unknown 15 41%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 16%
Medicine and Dentistry 5 14%
Nursing and Health Professions 4 11%
Immunology and Microbiology 3 8%
Agricultural and Biological Sciences 1 3%
Other 3 8%
Unknown 15 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2018.
All research outputs
#14,423,597
of 23,102,082 outputs
Outputs from BMC Infectious Diseases
#3,851
of 7,752 outputs
Outputs of similar age
#187,630
of 334,198 outputs
Outputs of similar age from BMC Infectious Diseases
#76
of 164 outputs
Altmetric has tracked 23,102,082 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,752 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,198 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.