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ZIFA: Dimensionality reduction for zero-inflated single-cell gene expression analysis

Overview of attention for article published in Genome Biology, November 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

blogs
2 blogs
twitter
42 X users
facebook
2 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
1 Google+ user

Citations

dimensions_citation
575 Dimensions

Readers on

mendeley
625 Mendeley
citeulike
4 CiteULike
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Title
ZIFA: Dimensionality reduction for zero-inflated single-cell gene expression analysis
Published in
Genome Biology, November 2015
DOI 10.1186/s13059-015-0805-z
Pubmed ID
Authors

Emma Pierson, Christopher Yau

Abstract

Single-cell RNA-seq data allows insight into normal cellular function and various disease states through molecular characterization of gene expression on the single cell level. Dimensionality reduction of such high-dimensional data sets is essential for visualization and analysis, but single-cell RNA-seq data are challenging for classical dimensionality-reduction methods because of the prevalence of dropout events, which lead to zero-inflated data. Here, we develop a dimensionality-reduction method, (Z)ero (I)nflated (F)actor (A)nalysis (ZIFA), which explicitly models the dropout characteristics, and show that it improves modeling accuracy on simulated and biological data sets.

X Demographics

X Demographics

The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 625 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 1%
United Kingdom 5 <1%
Sweden 2 <1%
Hungary 1 <1%
Denmark 1 <1%
Netherlands 1 <1%
Unknown 607 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 169 27%
Researcher 99 16%
Student > Master 56 9%
Student > Bachelor 52 8%
Student > Doctoral Student 40 6%
Other 85 14%
Unknown 124 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 129 21%
Agricultural and Biological Sciences 128 20%
Computer Science 99 16%
Mathematics 34 5%
Engineering 22 4%
Other 73 12%
Unknown 140 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2021.
All research outputs
#1,018,753
of 25,373,627 outputs
Outputs from Genome Biology
#727
of 4,467 outputs
Outputs of similar age
#15,417
of 296,360 outputs
Outputs of similar age from Genome Biology
#22
of 86 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.