↓ Skip to main content

What have we learned from clinical trials in primary Sjögren's syndrome about pathogenesis?

Overview of attention for article published in Arthritis Research & Therapy, January 2011
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
28 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
What have we learned from clinical trials in primary Sjögren's syndrome about pathogenesis?
Published in
Arthritis Research & Therapy, January 2011
DOI 10.1186/ar3234
Pubmed ID
Authors

Cees GM Kallenberg, Arjan Vissink, Frans GM Kroese, Wayel H Abdulahad, Hendrika Bootsma

Abstract

In vitro and in vivo experimental data have pointed to new immunopathogenic mechanisms in primary Sjögren's syndrome (pSS). The availability of targeted treatment modalities has opened new ways to selectively target these mechanistic pathways in vivo. This has taught us that the role of proinflammatory cytokines, in particular TNFα, is not crucial in the immunopathogenesis of pSS. B cells appear to play a major role, as depletion of B cells leads to restoration of salivary flow and is efficacious for treatment of extraglandular manifestations and mucosa-associated lymphoid tissue lymphoma. B cells also orchestrate T-cell infiltration and ductal epithelial dearrangement in the salivary glands. Gene profiling of salivary gland tissue in relation to B-cell depletion confirms that the axis of IFNα, B-cell activating factor, B-cell activation, proliferation and survival constitutes a major pathogenic route in pSS.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 25%
Student > Postgraduate 4 14%
Student > Master 4 14%
Student > Ph. D. Student 4 14%
Professor 2 7%
Other 6 21%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 19 68%
Biochemistry, Genetics and Molecular Biology 4 14%
Immunology and Microbiology 1 4%
Agricultural and Biological Sciences 1 4%
Unknown 3 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2011.
All research outputs
#2,325,425
of 4,506,407 outputs
Outputs from Arthritis Research & Therapy
#564
of 1,080 outputs
Outputs of similar age
#99,250
of 230,479 outputs
Outputs of similar age from Arthritis Research & Therapy
#69
of 113 outputs
Altmetric has tracked 4,506,407 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,080 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,479 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.