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Diversity of virulence level phenotype of hypervirulent Klebsiella pneumoniae from different sequence type lineage

Overview of attention for article published in BMC Microbiology, August 2018
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Title
Diversity of virulence level phenotype of hypervirulent Klebsiella pneumoniae from different sequence type lineage
Published in
BMC Microbiology, August 2018
DOI 10.1186/s12866-018-1236-2
Pubmed ID
Authors

Qiucheng Shi, Peng Lan, Danyan Huang, Xiaoting Hua, Yan Jiang, Jiancang Zhou, Yunsong Yu

Abstract

Hypervirulent Klebsiella pneumoniae (hvKP) is emerging around the Asian-Pacific region and it is the major cause of the community-acquired pyogenic liver abscesses. Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) isolates were reported in France, China and Taiwan. However, the international-ally agreed definition for hvKP and the virulence level of hvKP are not clear. In this study, 56 hvKP isolates were collected from March 2008 to June 2012 and investigated by string test, capsule serotyping, multilocus sequence typing (MLST), virulence gene detection and serum resistance assay. Among the 56 K. pneumoniae isolates, 64.3% had the hypermucoviscosity phenotype, meanwhile, 64.3% were the K1 serotype and 19.6% were the K2 serotype. Within the K1 serotype, 94.4% were ST23, and within the K2 serotype, ST65, ST86 and ST375 accounted for the same percentage 27.3%. The serum resistance showed statistically normal distribution. According to the 50% lethal dose of Galleria. mellonella infection model, hvKP isolates were divided into high virulence level group and moderate virulence level group. The ability of each method evaluating the virulence level of hvKP was assessed using the area under the receiver operating characteristic curve. K1 ST23 K. pneumoniae was the most prevalent clone of the hvKP. However, K1 ST23 K. pneumoniae was the dominant clone in the moderate virulence level group. MLST was a relatively reliable evaluation method to discriminate the virulence level of hvKP in our study.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 17%
Student > Master 12 17%
Researcher 9 13%
Student > Doctoral Student 4 6%
Student > Bachelor 4 6%
Other 10 14%
Unknown 19 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 24%
Immunology and Microbiology 13 19%
Medicine and Dentistry 11 16%
Agricultural and Biological Sciences 2 3%
Nursing and Health Professions 2 3%
Other 4 6%
Unknown 21 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
All research outputs
#15,544,609
of 23,102,082 outputs
Outputs from BMC Microbiology
#1,783
of 3,217 outputs
Outputs of similar age
#212,105
of 335,220 outputs
Outputs of similar age from BMC Microbiology
#28
of 54 outputs
Altmetric has tracked 23,102,082 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,217 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,220 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.