Title |
H. pylori infection and extra-gastroduodenal diseases
|
---|---|
Published in |
Journal of Biomedical Science, August 2018
|
DOI | 10.1186/s12929-018-0469-6 |
Pubmed ID | |
Authors |
Feng-Woei Tsay, Ping-I Hsu |
Abstract |
Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with many biological processes and determine or influence the occurrence of many diseases outside the stomach. Currently, the role of H. pylori in idiopathic thrombocytopenic purpura and iron deficiency anemia is well documented. Emerging evidence suggests that it may also contribute to vitamin B12 deficiency, insulin resistance, metabolic syndrome, diabetes mellitus and non-alcoholic liver disease. Additionally, it may increase the risk of acute coronary syndrome, cerebrovascular disease, neurodegenerative disease and other miscellaneous disorders. Different pathogenic mechanisms have been hypothesized, including the occurrence of molecular mimicry and the induction of a low-grade inflammation. This review summarizes the results of the most relevant studies on the extra-gastroduodenal manifestations of H. pylori infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Antigua and Barbuda | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 197 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 24 | 12% |
Student > Bachelor | 22 | 11% |
Researcher | 17 | 9% |
Student > Postgraduate | 12 | 6% |
Student > Ph. D. Student | 12 | 6% |
Other | 27 | 14% |
Unknown | 83 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 45 | 23% |
Biochemistry, Genetics and Molecular Biology | 19 | 10% |
Immunology and Microbiology | 9 | 5% |
Nursing and Health Professions | 8 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 20 | 10% |
Unknown | 90 | 46% |