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The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

Overview of attention for article published in Molecular Cancer, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

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1 news outlet
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4 X users

Citations

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449 Dimensions

Readers on

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198 Mendeley
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Title
The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory
Published in
Molecular Cancer, November 2015
DOI 10.1186/s12943-015-0458-2
Pubmed ID
Authors

Eli Raveh, Imad J. Matouk, Michal Gilon, Abraham Hochberg

Abstract

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject of controversy, although accumulating data suggest that H19 is one of the major genes in cancer. It is actively involved in all stages of tumorigenesis and is expressed in almost every human cancer. In this review we delineate the various functions of H19 during the different stages in the complex process of tumor progression. H19 up-regulation allows cells to enter a "selfish" survival mode in response to stress conditions, such as destabilization of the genome and hypoxia, by accelerating their proliferation rate and increasing overall cellular resistance to stress. This response is tightly correlated with nullification, dysfunction or significant down-regulation of the master tumor suppressor gene P53. The growing evidence of H19's involvement in both proliferation and differentiation processes, together with its involvement in epithelial to mesenchymal transition (EMT) and also mesenchymal to epithelial transition (MET), has led us to conclude that some of the recent disputes and discrepancies arising from current research findings can be resolved from a viewpoint supporting the oncogenic properties of H19. According to a holistic approach, the versatile, seemingly contradictory functions of H19 are essential to, and differentially harnessed by, the tumor cell depending on its context within the process of tumor progression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 <1%
Unknown 197 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 21%
Researcher 33 17%
Student > Master 25 13%
Student > Bachelor 21 11%
Student > Postgraduate 10 5%
Other 27 14%
Unknown 41 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 65 33%
Agricultural and Biological Sciences 30 15%
Medicine and Dentistry 21 11%
Immunology and Microbiology 6 3%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 21 11%
Unknown 49 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2023.
All research outputs
#2,709,807
of 23,509,253 outputs
Outputs from Molecular Cancer
#149
of 1,778 outputs
Outputs of similar age
#39,610
of 286,831 outputs
Outputs of similar age from Molecular Cancer
#3
of 37 outputs
Altmetric has tracked 23,509,253 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,778 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,831 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.