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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases
|
|---|---|
| Published in |
Immunity & Ageing, November 2015
|
| DOI | 10.1186/s12979-015-0046-8 |
| Pubmed ID | |
| Authors |
Sandro Dattilo, Cesare Mancuso, Guido Koverech, Paola Di Mauro, Maria Laura Ontario, Cateno Concetto Petralia, Antonino Petralia, Luigi Maiolino, Agostino Serra, Edward J. Calabrese, Vittorio Calabrese |
| Abstract |
Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, provide more comprehensive overview of the interaction of proteins, as well as the interplay among processes involved in neuroprotection. Here by introducing the hormetic dose response concept, the mechanistic foundations and applications to the field of neuroprotection, we discuss the emerging role of heat shock protein as prominent member of vitagene network in neuroprotection and redox proteomics as a tool for investigating redox modulation of stress responsive vitagenes. Hormetic mechanisms are reviewed as possibility of targeted therapeutic manipulation in a cell-, tissue- and/or pathway-specific manner at appropriate points in the neurodegenerative disease process. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 16% |
| Student > Ph. D. Student | 13 | 14% |
| Researcher | 12 | 13% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 7 | 8% |
| Other | 17 | 19% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 17% |
| Medicine and Dentistry | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Neuroscience | 7 | 8% |
| Chemistry | 5 | 6% |
| Other | 20 | 22% |
| Unknown | 22 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2016.
All research outputs
#1,352,942
of 24,495,755 outputs
Outputs from Immunity & Ageing
#41
of 412 outputs
Outputs of similar age
#20,535
of 290,693 outputs
Outputs of similar age from Immunity & Ageing
#4
of 13 outputs
Altmetric has tracked 24,495,755 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 412 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,693 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.