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Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

Overview of attention for article published in Medical Gas Research, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 358)
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
1 news outlet
twitter
60 X users
patent
4 patents
facebook
11 Facebook pages
wikipedia
4 Wikipedia pages
googleplus
2 Google+ users
video
5 YouTube creators

Citations

dimensions_citation
206 Dimensions

Readers on

mendeley
141 Mendeley
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Title
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -
Published in
Medical Gas Research, October 2015
DOI 10.1186/s13618-015-0035-1
Pubmed ID
Authors

Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno

Abstract

Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4 % is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

X Demographics

X Demographics

The data shown below were collected from the profiles of 60 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Unknown 140 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 16%
Student > Master 19 13%
Researcher 17 12%
Other 9 6%
Student > Postgraduate 9 6%
Other 28 20%
Unknown 37 26%
Readers by discipline Count As %
Medicine and Dentistry 31 22%
Agricultural and Biological Sciences 12 9%
Sports and Recreations 9 6%
Chemistry 8 6%
Biochemistry, Genetics and Molecular Biology 7 5%
Other 33 23%
Unknown 41 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2024.
All research outputs
#577,226
of 25,571,620 outputs
Outputs from Medical Gas Research
#15
of 358 outputs
Outputs of similar age
#8,534
of 295,766 outputs
Outputs of similar age from Medical Gas Research
#1
of 2 outputs
Altmetric has tracked 25,571,620 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,766 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them