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Making SENSE - Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry

Overview of attention for article published in BMC Neurology, November 2015
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Title
Making SENSE - Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry
Published in
BMC Neurology, November 2015
DOI 10.1186/s12883-015-0486-y
Pubmed ID
Authors

Christoph Kellinghaus, Nicolas Lang, Andrea O. Rossetti, Stephan Rüegg, Christian Tilz, Eugen Trinka, Iris Unterberger, Zeljko Uzelac, Felix Rosenow

Abstract

Evidence regarding the different treatment options of status epilepticus (SE) in adults is scarce. Large randomized trials cover only one treatment at early stage and suggest the superiority of benzodiazepines over placebo, of intravenous lorazepam over intravenous diazepam or over intravenous phenytoin alone, and of intramuscular midazolam over intravenous lorazepam. However, many patients will not be treated successfully with the first treatment step. A large randomized trial covering the treatment of established status (ESETT) has just been funded recently by the NIH and will not start before 2015, with expected results in 2018; a trial on the treatment of refractory status with general anesthetics was terminated early due to insufficient recruitment. Therefore, a prospective multicenter observational registry was set up; this may help in clinical decision-making until results from randomized trials are available. SENSE is a prospective, multicenter registry for patients treated for SE. The primary objective is to document patient characteristics, treatment modalities and in-house outcome of consecutive adults admitted for SE treatment in each of the participating centres and to identify predictors of outcome. Pre-treatment, treatment-related and outcome variables are documented systematically. To allow for meaningful multivariate analysis in the patient subgroups with refractory SE, a cohort size of 1000 patients is targeted. The results of the study will provide information about risks and benefits of specific treatment steps in different patient groups with SE at different points of time. Thus, it will support clinical decision-making and, furthermore, it will be helpful in the planning of treatment trials. DRKS00000725.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Japan 1 2%
Ethiopia 1 2%
Unknown 37 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 24%
Student > Ph. D. Student 5 12%
Student > Bachelor 4 10%
Professor > Associate Professor 4 10%
Student > Master 4 10%
Other 9 22%
Unknown 5 12%
Readers by discipline Count As %
Medicine and Dentistry 19 46%
Psychology 5 12%
Neuroscience 4 10%
Agricultural and Biological Sciences 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 3 7%
Unknown 5 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2015.
All research outputs
#11,404,977
of 12,827,217 outputs
Outputs from BMC Neurology
#1,300
of 1,440 outputs
Outputs of similar age
#230,098
of 278,083 outputs
Outputs of similar age from BMC Neurology
#171
of 195 outputs
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