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Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan

Overview of attention for article published in Alzheimer's Research & Therapy, November 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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Title
Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan
Published in
Alzheimer's Research & Therapy, November 2015
DOI 10.1186/s13195-015-0150-1
Pubmed ID
Authors

Yi-Hua Sun, Oswald Ndi Nfor, Jing-Yang Huang, Yung-Po Liaw

Abstract

The potential effects of amalgam fillings on the development of Alzheimer's disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer's disease in Taiwanese population aged 65 and older. Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer's disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0. Individuals exposed to amalgam fillings had higher risk of Alzheimer's disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women. Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer's disease than were their non-exposed counterparts.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 21%
Student > Master 12 16%
Student > Ph. D. Student 8 11%
Student > Doctoral Student 5 7%
Student > Postgraduate 5 7%
Other 14 18%
Unknown 16 21%
Readers by discipline Count As %
Medicine and Dentistry 32 42%
Agricultural and Biological Sciences 5 7%
Nursing and Health Professions 5 7%
Environmental Science 3 4%
Veterinary Science and Veterinary Medicine 2 3%
Other 12 16%
Unknown 17 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 83. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2023.
All research outputs
#487,002
of 24,549,201 outputs
Outputs from Alzheimer's Research & Therapy
#63
of 1,367 outputs
Outputs of similar age
#7,238
of 288,147 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#2
of 18 outputs
Altmetric has tracked 24,549,201 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,367 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,147 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.