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Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, November 2015
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1 tweeter
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3 Facebook pages

Citations

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15 Dimensions

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44 Mendeley
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Title
Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, November 2015
DOI 10.1186/s40409-015-0046-3
Pubmed ID
Authors

Andrea Casella-Martins, Lorena R Ayres, Sandra M Burin, Fabiana R Morais, Juliana C Pereira, Lucia H Faccioli, Suely V Sampaio, Eliane C Arantes, Fabiola A Castro, Luciana S Pereira-Crott

Abstract

Tityus serrulatus scorpion venom (TsV) contains toxins that act on K(+) and Na(+) channels and account for the venom's toxic effects. TsV can activate murine peritoneal macrophages, but its effects on human lymphocytes have been poorly investigated. Considering that lymphocytes may play an important role in envenomation, we assessed whether TsV affects the expression of phenotypic (CD3, CD4, and CD8) and activation (CD69, CD25, and HLA-DR) markers, cell proliferation, and cytokine production in peripheral blood mononuclear cells. Cytotoxicity of TsV was evaluated via the MTT assay. Cell proliferation, expression of phenotypic and activation markers, and release of cytokines were assessed using flow cytometry, after treatment with non-cytotoxic concentrations of TsV. The combined use of carboxyfluorescein diacetate succinimidyl ester and monoclonal antibodies against phenotypic and activation markers enabled us to simultaneously assess cell proliferation extent and cell activation status, and to discriminate among cell subpopulations. TsV at concentrations of 25 to 100 μg/mL were not cytotoxic towards peripheral blood mononuclear cells. TsV did not induce significant changes in lymphocyte subpopulations or in the expression of activation markers on CD4(+) and CD8(+) T cells. TsV inhibited the phytohemagglutinin-stimulated lymphocyte proliferation, particularly in the CD8(+) CD25(+) T lymphocyte subset. TsV alone, at 50 and 100 μg/mL, did not induce peripheral blood mononuclear cell proliferation, but elicited the production and release of IL-6, a proinflammatory cytokine that plays an important role in innate and adaptive immune responses. TsV is a potential source of molecules with immunomodulatory action on human T lymphocytes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Madagascar 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 23%
Student > Master 9 20%
Student > Ph. D. Student 7 16%
Student > Doctoral Student 4 9%
Professor 1 2%
Other 3 7%
Unknown 10 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 20%
Agricultural and Biological Sciences 7 16%
Immunology and Microbiology 7 16%
Pharmacology, Toxicology and Pharmaceutical Science 5 11%
Medicine and Dentistry 3 7%
Other 3 7%
Unknown 10 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2015.
All research outputs
#2,940,310
of 6,602,221 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#96
of 229 outputs
Outputs of similar age
#102,941
of 209,737 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#7
of 15 outputs
Altmetric has tracked 6,602,221 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 229 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,737 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.