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Variable responses of human and non-human primate gut microbiomes to a Western diet

Overview of attention for article published in Microbiome, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

twitter
36 tweeters
facebook
1 Facebook page

Citations

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71 Dimensions

Readers on

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160 Mendeley
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Title
Variable responses of human and non-human primate gut microbiomes to a Western diet
Published in
Microbiome, November 2015
DOI 10.1186/s40168-015-0120-7
Pubmed ID
Authors

Katherine R. Amato, Carl J. Yeoman, Gabriela Cerda, Christopher A. Schmitt, Jennifer Danzy Cramer, Margret E. Berg Miller, Andres Gomez, Trudy R. Turner, Brenda A. Wilson, Rebecca M. Stumpf, Karen E. Nelson, Bryan A. White, Rob Knight, Steven R. Leigh

Abstract

The human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models, including non-human primates. However, due to unique aspects of human diet and physiology, it is likely that host-gut microbe interactions operate differently in humans and non-human primates. Here, we show that the human microbiome reacts differently to a high-protein, high-fat Western diet than that of a model primate, the African green monkey, or vervet (Chlorocebus aethiops sabaeus). Specifically, humans exhibit increased relative abundance of Firmicutes and reduced relative abundance of Prevotella on a Western diet while vervets show the opposite pattern. Predictive metagenomics demonstrate an increased relative abundance of genes associated with carbohydrate metabolism in the microbiome of only humans consuming a Western diet. These results suggest that the human gut microbiota has unique properties that are a result of changes in human diet and physiology across evolution or that may have contributed to the evolution of human physiology. Therefore, the role of animal models for understanding the relationship between the human gut microbiota and host metabolism must be re-focused.

Twitter Demographics

The data shown below were collected from the profiles of 36 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 1%
Germany 1 <1%
South Africa 1 <1%
Finland 1 <1%
United States 1 <1%
Unknown 154 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 22%
Researcher 31 19%
Student > Bachelor 23 14%
Student > Master 19 12%
Student > Doctoral Student 8 5%
Other 19 12%
Unknown 25 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 61 38%
Biochemistry, Genetics and Molecular Biology 22 14%
Immunology and Microbiology 16 10%
Medicine and Dentistry 6 4%
Chemistry 3 2%
Other 18 11%
Unknown 34 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2019.
All research outputs
#1,263,018
of 20,115,055 outputs
Outputs from Microbiome
#476
of 1,206 outputs
Outputs of similar age
#20,455
of 248,703 outputs
Outputs of similar age from Microbiome
#30
of 79 outputs
Altmetric has tracked 20,115,055 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,206 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,703 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.