CCR5del32 genotype in human enteroviral cardiomyopathy leads to spontaneous virus clearance and improved outcome compared to wildtype CCR5

2/2) ‘CCR5del32 genotype’ in human enteroviral cardiomyopathy leads to spontaneous virus clearance & improved outcome compared to WT CCR5. The ‘ ’(hetero or homozygous) is clearly associated w complete spontaneous elimination of myocardial EV. Thanks

1/2) “Since macrophage-tropic HIV strains use CCR5 as co-receptor for entry to human cells, (CCRdel 32) homozygosity results in reduced susceptibility to these HIV strains.” https://t.co/oQJWx6ghAK Conformational change in HIV gp120 promotes binding to

⑤ Adipose / MΦ (←Mono) In both adipocytes & adipose tissue MΦs, entry could occur via an alternate receptor. In MΦs, entry could also occur via phagocytosis of viral particles or infected cells, or, Ab (if present)-dependently. #SARSCoV2 https://t.c

2/2) “CCR5del32 genotype in human enteroviral cardiomyopathy leads to spontaneous virus clearance and improved outcome compared to wildtype CCR5.” https://t.co/naleBLJ1RG