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Identification of novel reassortant mammalian orthoreoviruses from bats in Slovenia

Overview of attention for article published in BMC Veterinary Research, September 2018
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Title
Identification of novel reassortant mammalian orthoreoviruses from bats in Slovenia
Published in
BMC Veterinary Research, September 2018
DOI 10.1186/s12917-018-1585-y
Pubmed ID
Authors

Tina Naglič, Danijela Rihtarič, Peter Hostnik, Nataša Toplak, Simon Koren, Urška Kuhar, Urška Jamnikar-Ciglenečki, Denis Kutnjak, Andrej Steyer

Abstract

Recently, mammalian orthoreoviruses (MRVs) were detected for the first time in European bats, and the closely related strain SI-MRV01 was isolated from a child with severe diarrhoea in Slovenia. Genetically similar strains have also been reported from other mammals, which reveals their wide host distribution. The aim of this study was to retrospectively investigate the occurrence and genetic diversity of MRVs in bats in Slovenia, from samples obtained throughout the country in 2008 to 2010, and in 2012 and to investigate the occurrence of the novel SI-MRV01 MRV variant in Slovenian bats. The detection of MRVs in bat guano was based on broad-range RT-PCR and specific bat MRV real-time RT-PCR. Subsequently, MRV isolates were obtained from cell culture propagation, with detailed molecular characterisation through whole-genome sequencing. Overall, bat MRVs were detected in 1.9% to 3.8% of bats in 2008, 2009 and 2012. However, in 2010 the prevalence was 33.0%, which defined an outbreak of the single SI-MRV01 strain. Here, we report on the identification of five MRV isolates of different serotypes that are designated as SI-MRV02, SI-MRV03, SI-MRV04, SI-MRV05 and SI-MRV06. There is high genetic variability between these characterised isolates, with evident genome reassortment seen across their genome segments. In conclusion, we have confirmed the presence of the SI-MRV01 strain in a Slovenian bat population. Moreover, according to genetic characterisation of S1 genome segment, all three MRV serotypes were present in the bat population. In this study, five independent MRV isolates were obtained and detailed whole genome analysis revealed high diversity between them. This study generates new information about the epidemiology and molecular characteristics of emerging bat MRV variants, and provides important molecular data for further studies of their pathogenesis and evolution.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 16%
Student > Bachelor 2 11%
Student > Doctoral Student 2 11%
Professor > Associate Professor 2 11%
Researcher 1 5%
Other 1 5%
Unknown 8 42%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 21%
Immunology and Microbiology 3 16%
Agricultural and Biological Sciences 3 16%
Veterinary Science and Veterinary Medicine 1 5%
Unknown 8 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2021.
All research outputs
#14,815,837
of 19,215,644 outputs
Outputs from BMC Veterinary Research
#1,431
of 2,663 outputs
Outputs of similar age
#202,201
of 288,274 outputs
Outputs of similar age from BMC Veterinary Research
#1
of 1 outputs
Altmetric has tracked 19,215,644 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,663 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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