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Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity

Overview of attention for article published in Journal for Immunotherapy of Cancer, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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82 X users
googleplus
1 Google+ user

Citations

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126 Dimensions

Readers on

mendeley
108 Mendeley
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Title
Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity
Published in
Journal for Immunotherapy of Cancer, September 2018
DOI 10.1186/s40425-018-0398-7
Pubmed ID
Authors

Orneala Bakos, Christine Lawson, Samuel Rouleau, Lee-Hwa Tai

Abstract

Cancer surgery is necessary and life-saving. However, the majority of patients develop postoperative recurrence and metastasis, which are the main causes of cancer-related deaths. The postoperative stress response encompasses a broad set of physiological changes that have evolved to safeguard the host following major tissue trauma. These stress responses, however, intersect with cellular mediators and signaling pathways that contribute to cancer proliferation. MAIN: Previous descriptive and emerging mechanistic studies suggest that the surgery-induced prometastatic effect is linked to impairment of both innate and adaptive immunity. Existing studies that combine surgery and immunotherapies have revealed that this combination strategy is not straightforward and patients have experienced both therapeutic benefit and drawbacks. This review will specifically assess the immunological pathways that are disrupted by oncologic surgical stress and provide suggestions for rationally combining cancer surgery with immunotherapies to improve immune and treatment outcomes. Given the prevalence of surgery as frontline therapy for solid cancers, the emerging data on postoperative immunosuppression and the rapid development of immunotherapy for oncologic treatment, we believe that future targeted studies of perioperative immunotherapy are warranted.

X Demographics

X Demographics

The data shown below were collected from the profiles of 82 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 15%
Student > Ph. D. Student 11 10%
Researcher 11 10%
Student > Doctoral Student 10 9%
Other 9 8%
Other 20 19%
Unknown 31 29%
Readers by discipline Count As %
Medicine and Dentistry 34 31%
Biochemistry, Genetics and Molecular Biology 14 13%
Immunology and Microbiology 9 8%
Agricultural and Biological Sciences 8 7%
Engineering 2 2%
Other 5 5%
Unknown 36 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2023.
All research outputs
#872,985
of 25,498,750 outputs
Outputs from Journal for Immunotherapy of Cancer
#205
of 3,451 outputs
Outputs of similar age
#18,443
of 345,893 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#1
of 31 outputs
Altmetric has tracked 25,498,750 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.