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A quantitative analysis of therapeutic cancer vaccines in phase 2 or phase 3 trial

Overview of attention for article published in Journal for Immunotherapy of Cancer, November 2015
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Title
A quantitative analysis of therapeutic cancer vaccines in phase 2 or phase 3 trial
Published in
Journal for Immunotherapy of Cancer, November 2015
DOI 10.1186/s40425-015-0093-x
Pubmed ID
Authors

Amabel CL Tan, Anne Goubier, Holbrook E. Kohrt

Abstract

Despite the progress that has been made in other forms of cancer therapy, Provenge® (Sipuleucel-T) is the only FDA-approved vaccine for the treatment of cancer. To understand the current landscape of therapeutic oncology vaccines we performed a quantitative analysis of phase 2 and phase 3 therapeutic cancer vaccine trials. We highlight shifts in trends for the vaccine platforms examined, common adjuvant use, target indications, antibody or treatment combinations between past and recent trials as well as discuss the relationship between these trends and ratio between the number of phase 3: phase 2 for different vaccine platforms. Despite the poor success rate in vaccine approvals, registration of phase 3 trials between 2010 and 2014 were stable indicating continued investment and efforts towards development of immunotherapeutic vaccines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 91 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 22%
Student > Ph. D. Student 13 14%
Student > Bachelor 10 11%
Student > Master 6 7%
Other 5 5%
Other 15 16%
Unknown 23 25%
Readers by discipline Count As %
Medicine and Dentistry 17 18%
Agricultural and Biological Sciences 12 13%
Immunology and Microbiology 11 12%
Biochemistry, Genetics and Molecular Biology 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 16 17%
Unknown 26 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Journal for Immunotherapy of Cancer
#2,887
of 3,421 outputs
Outputs of similar age
#237,385
of 392,667 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#78
of 98 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,667 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.