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Identification of putative adhesins of Actinobacillus suis and their homologues in other members of the family Pasteurellaceae

Overview of attention for article published in BMC Research Notes, November 2015
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Title
Identification of putative adhesins of Actinobacillus suis and their homologues in other members of the family Pasteurellaceae
Published in
BMC Research Notes, November 2015
DOI 10.1186/s13104-015-1659-x
Pubmed ID
Authors

Adina R. Bujold, Janet I. MacInnes

Abstract

Actinobacillus suis disease has been reported in a wide range of vertebrate species, but is most commonly found in swine. A. suis is a commensal of the tonsils of the soft palate of swine, but in the presence of unknown stimuli it can invade the bloodstream, causing septicaemia and sequelae such as meningitis, arthritis, and death. It is genotypically and phenotypically similar to A. pleuropneumoniae, the causative agent of pleuropneumonia, and to other members of the family Pasteurellaceae that colonise tonsils. At present, very little is known about the genes involved in attachment, colonisation, and invasion by A. suis (or related members of the tonsil microbiota). Bioinformatic analyses of the A. suis H91-0380 genome were done using BASys and blastx in GenBank. Forty-seven putative adhesin-associated genes predicted to encode 24 putative adhesins were discovered. Among these are 6 autotransporters, 25 fimbriae-associated genes (encoding 3 adhesins), 12 outer membrane proteins, and 4 additional genes (encoding 3 adhesins). With the exception of 2 autotransporter-encoding genes (aidA and ycgV), both with described roles in virulence in other species, all of the putative adhesin-associated genes had homologues in A. pleuropneumoniae. However, the majority of the closest homologues of the A. suis adhesins are found in A. ureae and A. capsulatus-species not known to infect swine, but both of which can cause systemic infections. A. suis and A. pleuropneumoniae share many of the same putative adhesins, suggesting that the different diseases, tissue tropism, and host range of these pathogens are due to subtle genetic differences, or perhaps differential expression of virulence factors during infection. However, many of the putative adhesins of A. suis share even greater homology with those of other pathogens within the family Pasteurellaceae. Similar to A. suis, these pathogens (A. capsulatus and A. ureae) cause systemic infections and it is tempting to speculate that they employ similar strategies to invade the host, but more work is needed before that assertion can be made. This work begins to examine adhesin-associated factors that allow some members of the family Pasteurellaceae to invade the bloodstream while others cause a more localised infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 25%
Student > Doctoral Student 2 8%
Other 2 8%
Student > Master 2 8%
Student > Ph. D. Student 2 8%
Other 3 13%
Unknown 7 29%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 5 21%
Biochemistry, Genetics and Molecular Biology 5 21%
Agricultural and Biological Sciences 2 8%
Medicine and Dentistry 2 8%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 8 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#20,296,405
of 22,833,393 outputs
Outputs from BMC Research Notes
#3,559
of 4,264 outputs
Outputs of similar age
#235,706
of 281,503 outputs
Outputs of similar age from BMC Research Notes
#144
of 183 outputs
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