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Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study

Overview of attention for article published in Respiratory Research, November 2015
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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3 X users
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1 Google+ user

Citations

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54 Dimensions

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112 Mendeley
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Title
Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study
Published in
Respiratory Research, November 2015
DOI 10.1186/s12931-015-0299-y
Pubmed ID
Authors

P. E. Silkoff, I. Strambu, M. Laviolette, D. Singh, J. M. FitzGerald, S. Lam, S. Kelsen, A. Eich, A. Ludwig-Sengpiel, G. C hupp, V. Backer, C. Porsbjerg, P. O. Girodet, P. Berger, R. Leigh, J. N. Kline, M. Dransfield, W. Calhoun, A. Hussaini, S. Khatri, P. Chanez, V. S. Susulic, E. S. Barnathan, M. Curran, A. M. Das, C. Brodmerkel, F. Baribaud, M. J. Loza

Abstract

Asthma is a heterogeneous disease and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. The purpose of the ADEPT study was to correlate clinical features and biomarkers with molecular characteristics, by profiling asthma (NCT01274507). This report presents for the first time the study design, and characteristics of the recruited subjects. Patients with a range of asthma severity and healthy non-atopic controls were enrolled. The asthmatic subjects were followed for 12 months. Assessments included history, patient questionnaires, spirometry, airway hyper-responsiveness to methacholine, fractional exhaled nitric oxide (FENO), and biomarkers measured in induced sputum, blood, and bronchoscopy samples. All subjects underwent sputum induction and 30 subjects/cohort had bronchoscopy. Mild (n = 52), moderate (n = 55), severe (n = 51) asthma cohorts and 30 healthy controls were enrolled from North America and Western Europe. Airflow obstruction, bronchodilator response and airways hyperresponsiveness increased with asthma severity, and severe asthma subjects had reduced forced vital capacity. Asthma control questionnaire-7 (ACQ7) scores worsened with asthma severity. In the asthmatics, mean values for all clinical and biomarker characteristics were stable over 12 months although individual variability was evident. FENO and blood eosinophils did not differ by asthma severity. Induced sputum eosinophils but not neutrophils were lower in mild compared to the moderate and severe asthma cohorts. The ADEPT study successfully enrolled asthmatics across a spectrum of severity and non-atopic controls. Clinical characteristics were related to asthma severity and in general asthma characteristics e.g. lung function, were stable over 12 months. Use of the ADEPT data should prove useful in defining biological phenotypes to facilitate personalized therapeutic approaches.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 112 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 17%
Researcher 17 15%
Student > Ph. D. Student 11 10%
Student > Bachelor 9 8%
Other 6 5%
Other 23 21%
Unknown 27 24%
Readers by discipline Count As %
Medicine and Dentistry 46 41%
Biochemistry, Genetics and Molecular Biology 6 5%
Nursing and Health Professions 5 4%
Immunology and Microbiology 4 4%
Agricultural and Biological Sciences 2 2%
Other 15 13%
Unknown 34 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2016.
All research outputs
#14,388,554
of 25,374,647 outputs
Outputs from Respiratory Research
#1,347
of 3,062 outputs
Outputs of similar age
#185,076
of 392,667 outputs
Outputs of similar age from Respiratory Research
#16
of 36 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,667 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.