Title |
Neurotoxic syndrome induced by clomipramine plus risperidone in a patient with autistic spectrum disorder: serotonin or neuroleptic malignant syndrome?
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Published in |
Annals of General Psychiatry, November 2015
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DOI | 10.1186/s12991-015-0073-z |
Pubmed ID | |
Authors |
Kalliopi N. Nikolaou, Rossetos Gournellis, Ioannis Michopoulos, Georgios Dervenoulas, Christos Christodoulou, Athanasios Douzenis |
Abstract |
To the best of our knowledge, there are no case studies of serotonin syndrome (SS) in patients with autism spectrum disorder. We report the case of a 33-year-old male who presented SS under the combined use of clomipramine and risperidone. More specifically, within 2 days after clomipramine (10 mg/BID-two times a day) was added to risperidone (4 mg/OD-once a day), mirtazapine 45 mg/OD and alprazolam (0,5 mg/TID-three times a day) he began to present mental, neurological and autonomic symptoms. All his psychopathological manifestations and laboratory findings normalized after the above-mentioned drugs' discontinuation, and the administration of supportive medical care and lorazepam 2,5 mg/TID. The diagnosis of serotonin syndrome was challenging due to the relatively low dose of clomipramine, an increase of risperidone which had taken place before clomipramine administration and clinical symptoms which could be attributed to both serotonin and neuroleptic malignant syndrome. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 22% |
Student > Master | 4 | 17% |
Researcher | 3 | 13% |
Student > Ph. D. Student | 2 | 9% |
Other | 1 | 4% |
Other | 3 | 13% |
Unknown | 5 | 22% |
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Medicine and Dentistry | 8 | 35% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Nursing and Health Professions | 2 | 9% |
Psychology | 2 | 9% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 2 | 9% |
Unknown | 6 | 26% |