Title |
NF-κB in inflammation and renal diseases
|
---|---|
Published in |
Cell & Bioscience, November 2015
|
DOI | 10.1186/s13578-015-0056-4 |
Pubmed ID | |
Authors |
Haisong Zhang, Shao-Cong Sun |
Abstract |
Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as inactive complexes via physical association with inhibitory proteins termed IκBs. In response to immune and stress stimuli, NF-κB members become activated via two major signaling pathways, the canonical and noncanonical pathways, and move to the nucleus to exert transcriptional functions. NF-κB is vital for normal immune responses against infections, but deregulated NF-κB activation is a major cause of inflammatory diseases. Accumulated studies suggest the involvement of NF-κB in the pathogenesis of renal inflammation caused by infection, injury, or autoimmune factors. In this review, we discuss the current understanding regarding the activation and function of NF-κB in different types of kidney diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 317 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 50 | 16% |
Student > Master | 43 | 14% |
Researcher | 27 | 9% |
Student > Bachelor | 24 | 8% |
Lecturer | 12 | 4% |
Other | 56 | 18% |
Unknown | 105 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 59 | 19% |
Medicine and Dentistry | 46 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 25 | 8% |
Agricultural and Biological Sciences | 21 | 7% |
Immunology and Microbiology | 15 | 5% |
Other | 31 | 10% |
Unknown | 120 | 38% |