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Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis

Overview of attention for article published in Biological Research, September 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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4 tweeters

Citations

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43 Dimensions

Readers on

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50 Mendeley
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Title
Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis
Published in
Biological Research, September 2018
DOI 10.1186/s40659-018-0182-7
Pubmed ID
Authors

Thais A. Jacinto, Giselle S. Meireles, Ananda T. Dias, Rafaela Aires, Marcella L. Porto, Agata L. Gava, Elisardo C. Vasquez, Thiago Melo C. Pereira, Bianca P. Campagnaro, Silvana S. Meyrelles

Abstract

New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally involved in progression and/or resolution of plaque in atherosclerosis, this concurrence has not yet been fully investigated. In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE-/-) mice compared with age-matched wild-type C57BL/6 (WT) mice. Experiments were performed in young (2-months) and in old (18-months) male wild-type (WT) and apoE-/- mice. Besides the expected differences in serum lipid profile and plaque formation, we observed that atherosclerotic mice exhibited a significant increase in monocytosis and in serum levels of pro-inflammatory cytokines compared to WT mice. Moreover, it was observed that the overproduction of ROS, led to an increased DNA fragmentation and, consequently, apoptosis in monocytes from normocholesterolemic old mice, which was aggravated in age-matched atherosclerotic mice. In this study, we demonstrate that a pro-inflammatory systemic status is associated with an impairment of functionality of monocytes during aging and that these parameters are fundamental extra-arterial contributors to the aggravation of atherosclerosis. The present data open new avenues for the development of future strategies with the purpose of treating atherosclerosis.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 14%
Student > Bachelor 7 14%
Researcher 6 12%
Student > Ph. D. Student 6 12%
Student > Postgraduate 3 6%
Other 7 14%
Unknown 14 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 26%
Medicine and Dentistry 5 10%
Immunology and Microbiology 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Agricultural and Biological Sciences 2 4%
Other 8 16%
Unknown 16 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2018.
All research outputs
#8,853,269
of 16,058,965 outputs
Outputs from Biological Research
#108
of 429 outputs
Outputs of similar age
#129,788
of 277,526 outputs
Outputs of similar age from Biological Research
#1
of 1 outputs
Altmetric has tracked 16,058,965 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 429 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,526 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them