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Biofilm-associated proteins: news from Acinetobacter

Overview of attention for article published in BMC Genomics, November 2015
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Title
Biofilm-associated proteins: news from Acinetobacter
Published in
BMC Genomics, November 2015
DOI 10.1186/s12864-015-2136-6
Pubmed ID
Authors

Eliana De Gregorio, Mariateresa Del Franco, Marianna Martinucci, Emanuela Roscetto, Raffaele Zarrilli, Pier Paolo Di Nocera

Abstract

A giant protein called BAP (biofilm-associated protein) plays a role in biofilm formation and adhesion to host cells in A. baumannii. Most of the protein is made by arrays of 80-110 aa modules featuring immunoglobulin-like (Ig-like) motifs. The survey of 541 A. baumannii sequenced strains belonging to 108 STs (sequence types) revealed that BAP is highly polymorphic, distinguishable in three main types for changes both in the repetitive and the COOH region. Analyzing the different STs, we found that 29 % feature type-1, 40 % type-2 BAP, 11 % type-3 BAP, 20 % lack BAP. The type-3 variant is restricted to A. baumannii, type-1 and type-2 BAP have been identified also in other species of the Acinetobacter calcoaceticus-baumannii (ACB) complex. A. calcoaceticus and A. pittii also encode BAP-like proteins in which Ig-like repeats are replaced by long tracts of alternating serine and aspartic acid residues. We have identified in species of the ACB complex two additional proteins, BLP1 and BLP2 (BAP-like proteins 1 and 2) which feature Ig-like repeats, share with BAP a sequence motif at the NH2 terminus, and are similarly expressed in stationary growth phase. The knock-out of either BLP1 or BLP2 genes of the A. baumannii ST1 AYE strain severely affected biofilm formation, as measured by comparing biofilm biomass and thickness, and adherence to epithelial cells. BLP1 is missing in the majority of type-3 BAP strains. BLP2 is largely conserved, but is frequently missing in BAP-negative cells. Multiple proteins sharing Ig-like repeats seem to be involved in biofilm formation. The uneven distribution of the different BAP types, BLP1, and BLP2 is highly indicative that alternative protein complexes involved in biofilm formation are assembled in different A. baumannii strains.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 16%
Student > Ph. D. Student 11 15%
Student > Bachelor 8 11%
Student > Doctoral Student 7 9%
Student > Master 7 9%
Other 16 21%
Unknown 14 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 27%
Biochemistry, Genetics and Molecular Biology 12 16%
Immunology and Microbiology 12 16%
Medicine and Dentistry 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 7 9%
Unknown 17 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#13,799,584
of 15,640,884 outputs
Outputs from BMC Genomics
#7,596
of 8,778 outputs
Outputs of similar age
#299,838
of 366,509 outputs
Outputs of similar age from BMC Genomics
#944
of 1,005 outputs
Altmetric has tracked 15,640,884 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,778 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,005 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.