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The effects of thoracic epidural analgesia on oxygenation and pulmonary shunt fraction during one-lung ventilation: an meta-analysis

Overview of attention for article published in BMC Anesthesiology, November 2015
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Title
The effects of thoracic epidural analgesia on oxygenation and pulmonary shunt fraction during one-lung ventilation: an meta-analysis
Published in
BMC Anesthesiology, November 2015
DOI 10.1186/s12871-015-0142-5
Pubmed ID
Authors

Xiao-Qian Li, Wen-Fei Tan, Jun Wang, Bo Fang, Hong Ma

Abstract

The aim of our study is to compare the effects of thoracic epidural analgesia combined with general anesthesia (GA) vs. general anesthesia on oxygenation and pulmonary shunt fraction during one-lung ventilation (OLV). Literature research was firstly conducted for studies related to comparison of epidural anesthesia combined with GA vs. GA with reporting of hemodynamic and oxygenation variables and published from Jan 1990 to Jan 2014 in EMBAS, MEDLINE and Cochrane Central Register of Controlled Trials databases. The studies were reviewed and data were extracted and analyzed using fixed-effect and random-effect models. There are 14 trials with 60 separate comparisons enrolling 653 patients for analysis. Regarding systemic hemodynamics, thoracic epidural analgesia decreased the mean arterial pressure and mean pulmonary arterial pressure with weighted mean difference 95 % confidence interval (-6.64 [-9.57 to -3.71] vs. -6.33 [-9.25 to -3.41] and -3.18 [-5.07 to -1.28] vs. -2.05 [-3.35 to -0.75]) respectively at the two measurements time, however, only decreasing heart rate and systemic vascular resistance (-3.28 [-5.98 to -0.67] and -319.99 [-447.05 to -192.94]) over the first 30 min after OLV. For oxygenation variables, thoracic epidural analgesia is associated with significant reduction in partial arterial oxygen pressure, mixed arterial saturation of oxygenation and increased pulmonary venous admixture fraction compared to general anesthesia with weighted mean difference 95 % confidence interval (-16.52 [-21.98 to - 11.05] vs. - 14.23 [-20.81 to - 7.65]), (0.74 [0.33 to 1.15] vs. - 0.63 [-1.23 to -0.04]) and (2.53 [1.35 to 3.72] vs. 2.77 [1.81 to 3.74]) respectively before and after 30 min of one-lung ventilation. A decrease in mixed venous saturation of oxygenation occurred after 30 min of OLV (-2.39 [-3.73 to -0.99]). Besides, a higher mean value of airway pressure was found in the thoracic epidural analgesia with weighted mean difference 95 % confidence interval (1.95 [1.61 to 2.28] vs. 0.87 [0.54 to 1.20]) at the measurements. Based on the existing limited data puts forward recommendations for cautious usage of thoracic epidural analgesia in case of underlying risks in lower systemic hemodynamics, decreased partial arterial oxygen pressure but increases pulmonary shunt during one-lung ventilation.

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Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 15%
Lecturer 2 10%
Student > Bachelor 2 10%
Researcher 2 10%
Student > Postgraduate 2 10%
Other 3 15%
Unknown 6 30%
Readers by discipline Count As %
Medicine and Dentistry 14 70%
Unknown 6 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2016.
All research outputs
#18,430,915
of 22,833,393 outputs
Outputs from BMC Anesthesiology
#990
of 1,496 outputs
Outputs of similar age
#278,429
of 386,484 outputs
Outputs of similar age from BMC Anesthesiology
#25
of 38 outputs
Altmetric has tracked 22,833,393 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.