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Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells

Overview of attention for article published in Chinese Medicine, August 2018
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Title
Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells
Published in
Chinese Medicine, August 2018
DOI 10.1186/s13020-018-0203-z
Pubmed ID
Authors

Zhangfeng Zhong, Haibing Yu, Shengpeng Wang, Yitao Wang, Liao Cui

Abstract

Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese medicine may shed light on design of new therapeutic modes to overcome chemo-resistance. Although Rhizoma Curcumae possesses anti-cancer activities in various types of cancers, the effects and underlying mechanisms of its bioactive components against chemo-resistance are not clear. Therefore, the present study aims to explore the potential effects of Rhizoma Curcumae on doxorubicin-resistant breast cancer cells. The expression and function of ABC transporters in doxorubicin-resistant MCF-7 breast cancer cells were measured by western blotting and flow cytometry. Cell viability was detected using MTT assay. The combination index was analyzed using the CalcuSyn program (Biosoft, Ferguson, MO), based on the Chou-Talalay method. In our present study, P-gp was overexpressed at protein level in doxorubicin-resistant MCF-7 cell line, but short of MRP1 and BCRP1. Essential oil of Rhizoma Curcumae and the main bioactive components were assessed on doxorubicin-resistant MCF-7 cell line. We found that the essential oil and furanodiene both display powerful inhibitory effects on cell viability, but neither of these is the specific inhibitor of ABC transporters. Moreover, furanodiene fails to enhance the efficacy of doxorubicin to improve multidrug resistance. Overall, our findings fill the gaps of the researches on chemo-resistance improvement of Rhizoma Curcumae and are also beneficial for Rhizoma Curcumae being developed as a promising natural product for cancer adjuvant therapy in the future.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Student > Master 4 20%
Student > Bachelor 4 20%
Researcher 2 10%
Student > Doctoral Student 1 5%
Other 2 10%
Unknown 1 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 35%
Agricultural and Biological Sciences 3 15%
Chemistry 3 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Medicine and Dentistry 2 10%
Other 2 10%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2018.
All research outputs
#12,001,641
of 15,087,745 outputs
Outputs from Chinese Medicine
#212
of 327 outputs
Outputs of similar age
#204,219
of 274,061 outputs
Outputs of similar age from Chinese Medicine
#1
of 1 outputs
Altmetric has tracked 15,087,745 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 327 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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