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Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies

Overview of attention for article published in Arthritis Research & Therapy, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

news
1 news outlet

Citations

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13 Dimensions

Readers on

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35 Mendeley
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Title
Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies
Published in
Arthritis Research & Therapy, November 2015
DOI 10.1186/s13075-015-0850-8
Pubmed ID
Authors

Eduardo Gómez-Bañuelos, Rosa Elena Navarro-Hernández, Fernanda Corona-Meraz, Perla Monserrat Madrigal-Ruíz, Beatríz Teresita Martín-Marquez, Oscar Enrique Pizano-Martinez, Jorge Aguilar-Arreola, Paul Jacob Perez-Cruz, Hector Macias-Reyes, Laura Gonzalez-Lopez, Jorge Ivan Gamez-Nava, Mario Salazar-Páramo, Monica Vazquez-del Mercado

Abstract

Leptin has a prominent role in the development and maintenance of acute and chronic inflammatory states such as rheumatoid arthritis (RA) and obesity. Nevertheless, the association of serum leptin (sLep) and soluble leptin receptor (sLepR) in RA pathogenesis has not been clarified. The purpose of this study was to evaluate the association of sLep, sLepR and leptin production indexes such as sLep/fat mass ratio with clinical activity and biomarkers and anti-cyclic citrullinated peptide (anti-CCP) antibodies in RA compared with body mass index (BMI) matched control subjects. We included 64 RA patients and 66 controls matched for age, gender and BMI. Subjects were evaluated for BMI, fat mass distribution, sLep, sLepR, sLep/fat mass ratio and sLepR/fat mass ratio. Patients were evaluated for clinical activity and anti-CCP antibodies. We found two or three fold increased sLep levels, sLep/sLepR ratio and sLep/fat mass ratio in obese anti-CCP positive RA patients vs. Partial correlations showed that anti-CCP antibodies were correlated with sLep/fat mass ratio (partial r = 0.347, P = 0.033) after adjustment for age, subcutaneous adipose tissue and fat mass. In preobese and obese RA patients there is and increased production of sLep according to anti-CCP positivity. This phenomenon suggests there is an additive effect of chronic inflammation resulting from RA and obesity in which leptin favors the humoral response against citrullinated proteins. In summary, the data observed in our study suggests sLep could be a surrogate marker of chronicity and humoral immunity in RA in the presence of obesity.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
China 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 26%
Student > Master 5 14%
Professor 4 11%
Researcher 4 11%
Student > Postgraduate 3 9%
Other 5 14%
Unknown 5 14%
Readers by discipline Count As %
Medicine and Dentistry 12 34%
Biochemistry, Genetics and Molecular Biology 4 11%
Immunology and Microbiology 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Psychology 2 6%
Other 3 9%
Unknown 8 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2015.
All research outputs
#1,928,177
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#485
of 1,983 outputs
Outputs of similar age
#59,334
of 337,167 outputs
Outputs of similar age from Arthritis Research & Therapy
#108
of 288 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,167 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 288 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.