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Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients

Overview of attention for article published in Critical Care, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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19 X users
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1 Facebook page

Citations

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26 Dimensions

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56 Mendeley
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Title
Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-1125-0
Pubmed ID
Authors

Arie J. Hoogendijk, Maryse A. Wiewel, Lonneke A. van Vught, Brendon P. Scicluna, Hakima Belkasim-Bohoudi, Janneke Horn, Aeilko H. Zwinderman, Peter M. C. Klein Klouwenberg, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz, Tom van der Poll

Abstract

Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are elevated in sepsis and associate with outcome. The secondary objective was to determine whether fractalkine can assist in the diagnosis of infection upon ICU admission. Fractalkine was measured in 1103 consecutive sepsis patients (including 271 patients with community-acquired pneumonia (CAP)) upon ICU admission and at days 2 and 4 thereafter; in 73 ICU patients treated for suspected CAP in whom this diagnosis was refuted in retrospect; and in 5 healthy humans intravenously injected with endotoxin. Compared to healthy volunteers, sepsis patients had strongly elevated fractalkine levels. Fractalkine levels increased with the number of organs failing, were higher in patients presenting with shock, but did not vary by site of infection. Non-survivors had sustained elevated fractalkine levels when compared to survivors. Fractalkine was equally elevated in CAP patients and patients treated for CAP but in whom the diagnosis was retrospectively refuted. Fractalkine release induced by intravenous endotoxin followed highly similar kinetics as the endothelial cell marker E-selectin. Plasma fractalkine is an endothelial cell derived biomarker that, while not specific for infection, correlates with disease severity in sepsis patients admitted to the ICU.

X Demographics

X Demographics

The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 16%
Researcher 8 14%
Student > Master 7 13%
Student > Bachelor 6 11%
Other 6 11%
Other 6 11%
Unknown 14 25%
Readers by discipline Count As %
Medicine and Dentistry 31 55%
Engineering 2 4%
Agricultural and Biological Sciences 2 4%
Biochemistry, Genetics and Molecular Biology 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 5 9%
Unknown 14 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2015.
All research outputs
#3,248,060
of 25,371,288 outputs
Outputs from Critical Care
#2,641
of 6,554 outputs
Outputs of similar age
#51,177
of 395,397 outputs
Outputs of similar age from Critical Care
#214
of 466 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.