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Aptamer-labeled PLGA nanoparticles for targeting cancer cells

Overview of attention for article published in Cancer Nanotechnology, January 2012
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  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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1 tweeter
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1 patent

Citations

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40 Dimensions

Readers on

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54 Mendeley
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Title
Aptamer-labeled PLGA nanoparticles for targeting cancer cells
Published in
Cancer Nanotechnology, January 2012
DOI 10.1007/s12645-011-0024-6
Pubmed ID
Authors

Athulya Aravind, Saino Hanna Varghese, Srivani Veeranarayanan, Anila Mathew, Yutaka Nagaoka, Seiki Iwai, Takahiro Fukuda, Takashi Hasumura, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar

Abstract

Cancer is one of the leading causes of death in most parts of the world and is a very serious cause of concern particularly in developing countries. In this work, we prepared and evaluated the aptamer-labeled paclitaxel-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Apt-PTX-PLGA NPs) which can ameliorate drug bioavailability and enable accurate drug targeting to cancer cells with controlled drug release for cancer therapy. Paclitaxel-loaded PLGA nanoparticles (PTX-PLGA NPs) were formulated by a single-emulsion/solvent evaporation method and were further surface-functionalized with a chemical cross-linker bis(sulfosuccinimidyl) suberate (BS3) to enable binding of aptamer on to the surface of the nanoparticles. The prepared nanoparticles were characterized by atomic force microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Cytotoxicity studies were carried out using normal human mammary epithelial cells (HMEC cells) and human glial cancer cells (GI-1 cells) by methylthiazolyldiphenyl-tetrazolium bromide assay and Alamar blue assay, which confirmed that PTX-PLGA NPs with aptamer conjugation (Apt-PTX-PLGA NPs) were comparatively non-toxic to HMEC cells while toxic to GI-1 cancer cells. Cellular uptake of PTX-PLGA NPs with and without aptamer conjugation was studied using GI-1 cells and monitored by confocal microscopy and phase contrast microscopy. Our studies demonstrated significant internalization and retention of nanoparticles inside the cells, inducing apoptosis. The preferential accumulation of PTX-PLGA NPs within the cancer cells were also confirmed by flow cytometry-based uptake studies. The results indicated that Apt-PTX-PLGA NPs could be a promising targeted therapeutic delivery vehicle for cancer treatment.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 20%
Researcher 9 17%
Student > Master 9 17%
Student > Bachelor 5 9%
Student > Postgraduate 2 4%
Other 8 15%
Unknown 10 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 20%
Agricultural and Biological Sciences 11 20%
Chemistry 7 13%
Medicine and Dentistry 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 6 11%
Unknown 14 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2019.
All research outputs
#5,233,247
of 17,358,590 outputs
Outputs from Cancer Nanotechnology
#25
of 92 outputs
Outputs of similar age
#107,381
of 373,632 outputs
Outputs of similar age from Cancer Nanotechnology
#1
of 3 outputs
Altmetric has tracked 17,358,590 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 92 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 373,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them