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Distribution and frequency of G119S mutation in ace-1 gene within Anopheles sinensis populations from Guangxi, China

Overview of attention for article published in Malaria Journal, November 2015
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Title
Distribution and frequency of G119S mutation in ace-1 gene within Anopheles sinensis populations from Guangxi, China
Published in
Malaria Journal, November 2015
DOI 10.1186/s12936-015-1000-0
Pubmed ID
Authors

Xiangyang Feng, Chan Yang, Yichao Yang, Jun Li, Kangming Lin, Mei Li, Xinghui Qiu

Abstract

Malaria is one of the most serious vector-borne diseases in the world. Vector control is an important measure for malaria prevention and elimination. However, this strategy is under threat as disease vectors are developing resistance to insecticides. Therefore, it is important to monitor mechanisms responsible for insecticide resistance. In this study, the presence of G119S mutation in the acetyl cholinesterase-encoding gene (ace-1) was investigated in nine Anopheles sinensis populations sampled across Guangxi Zhuang Autonomous Region China. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method was used to genotype each individual adult of An. sinensis. Direct sequencing of PCR products was performed to verify the accuracy of PCR-RFLP genotyping result. Population genetics analysis was conducted using Genepop programme. The frequencies of susceptible homozygotes, heterozygotes and resistant homozygotes in the nine populations ranged between 0-0.296, 0.143-0.500 and 0.333-0.857, respectively. Overall, a high frequency (0.519-0.929) of mutant 119S allele was observed and the genotype frequency of the ace-1 gene of An. sinensis was at Hardy-Weinberg equilibrium in each of the nine examined populations. The G119S mutation has become fixed and is widespread in An. sinensis field populations in Guangxi, China. These findings are useful in helping design strategies for An. sinensis control.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ghana 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 20%
Researcher 8 16%
Student > Ph. D. Student 5 10%
Other 4 8%
Student > Master 4 8%
Other 9 18%
Unknown 11 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 24%
Biochemistry, Genetics and Molecular Biology 10 20%
Medicine and Dentistry 8 16%
Immunology and Microbiology 2 4%
Mathematics 1 2%
Other 5 10%
Unknown 13 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2015.
All research outputs
#20,297,343
of 22,834,308 outputs
Outputs from Malaria Journal
#5,333
of 5,572 outputs
Outputs of similar age
#324,093
of 386,751 outputs
Outputs of similar age from Malaria Journal
#134
of 145 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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