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Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease

Overview of attention for article published in Acta Neuropathologica Communications, September 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

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9 X users
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

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60 Dimensions

Readers on

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94 Mendeley
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Title
Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease
Published in
Acta Neuropathologica Communications, September 2018
DOI 10.1186/s40478-018-0596-z
Pubmed ID
Authors

Isabel Ortuño-Lizarán, Gema Esquiva, Thomas G. Beach, Geidy E. Serrano, Charles H. Adler, Pedro Lax, Nicolás Cuenca

Abstract

Parkinson's disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these processes and may be affected in PD, as other retinal and visual implications have been described in the disease. Number and morphology of human melanopsin-containing retinal ganglion cells were evaluated by immunohistochemistry in eyes from donors with PD or control. The Sholl number of intersections, the number of branches, and the number of terminals from the Sholl analysis were significantly reduced in PD melanopsin ganglion cells. Also, the density of these cells significantly decreased in PD compared to controls. Degeneration and impairment of the retinal melanopsin system may affect to sleep and circadian dysfunction reported in PD pathology, and its protection or stimulation may lead to better disease prospect and global quality of life of patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 94 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 16%
Student > Master 9 10%
Researcher 8 9%
Student > Bachelor 8 9%
Student > Doctoral Student 5 5%
Other 18 19%
Unknown 31 33%
Readers by discipline Count As %
Medicine and Dentistry 16 17%
Neuroscience 15 16%
Biochemistry, Genetics and Molecular Biology 7 7%
Nursing and Health Professions 4 4%
Agricultural and Biological Sciences 3 3%
Other 16 17%
Unknown 33 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2022.
All research outputs
#3,351,785
of 23,322,966 outputs
Outputs from Acta Neuropathologica Communications
#747
of 1,414 outputs
Outputs of similar age
#69,441
of 337,880 outputs
Outputs of similar age from Acta Neuropathologica Communications
#16
of 36 outputs
Altmetric has tracked 23,322,966 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,414 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,880 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.