Title |
Engineering and monitoring cellular barrier models
|
---|---|
Published in |
Journal of Biological Engineering, September 2018
|
DOI | 10.1186/s13036-018-0108-5 |
Pubmed ID | |
Authors |
Jose Yeste, Xavi Illa, Mar Alvarez, Rosa Villa |
Abstract |
Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is associated with numerous human diseases. Recent advances in biomaterials and microfabrication technologies have evolved in vitro approaches for modelling biological barriers. Current microphysiological systems have become more efficient and reliable in mimicking the cell microenvironment. Additionally, methods for the quantification of barrier permeability have long provided significant insight into their underlying mechanisms. In this review, we outline the current techniques to quantify the barrier function of engineered tissues, and we also give an overview of recent microphysiological systems of biological barriers that emulate the microenvironment and microarchitecture of native tissues. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 18% |
Germany | 1 | 9% |
France | 1 | 9% |
Netherlands | 1 | 9% |
Czechia | 1 | 9% |
United States | 1 | 9% |
Spain | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 73% |
Scientists | 3 | 27% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 172 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 37 | 22% |
Researcher | 30 | 17% |
Student > Master | 27 | 16% |
Student > Bachelor | 11 | 6% |
Student > Doctoral Student | 9 | 5% |
Other | 9 | 5% |
Unknown | 49 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 32 | 19% |
Biochemistry, Genetics and Molecular Biology | 23 | 13% |
Agricultural and Biological Sciences | 16 | 9% |
Medicine and Dentistry | 9 | 5% |
Chemistry | 8 | 5% |
Other | 28 | 16% |
Unknown | 56 | 33% |