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A-Part Gel, an adhesion prophylaxis for abdominal surgery: a randomized controlled phase I–II safety study [NCT00646412]

Overview of attention for article published in Annals of Surgical Innovation and Research, September 2015
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Title
A-Part Gel, an adhesion prophylaxis for abdominal surgery: a randomized controlled phase I–II safety study [NCT00646412]
Published in
Annals of Surgical Innovation and Research, September 2015
DOI 10.1186/s13022-015-0014-1
Pubmed ID
Authors

Reinhold Lang, Petra Baumann, Claudia Schmoor, Erich K. Odermatt, Moritz N. Wente, Karl-Walter Jauch

Abstract

Intra-abdominal surgical intervention can cause the development of intra-peritoneal adhesions. To reduce this problem, different agents have been tested to minimize abdominal adhesions; however, the optimal adhesion prophylaxis has not been found so far. Therefore, the A-Part(®) Gel was developed as a barrier to diminish postsurgical adhesions; the aim of this randomized controlled study was a first evaluation of its safety and efficacy. In this prospective, controlled, randomized, patient-blinded, monocenter phase I-II study, 62 patients received either the hydrogel A-Part-Gel(®) as an anti-adhesive barrier or were untreated after primary elective median laparotomy. Primary endpoint was the occurrence of peritonitis and/or wound healing impairment 28 ± 10 days postoperatively. As secondary endpoints anastomotic leakage until 28 days after surgery, adverse events and adhesions were assessed until 3 months postoperatively. A lower rate of wound healing impairment and/or peritonitis was observed in the A-Part Gel(®) group compared to the control group: (6.5 vs. 13.8 %). The difference between the two groups was -7.3%, 90 % confidence interval [-20.1, 5.4 %]. Both treatment groups showed similar frequency of anastomotic leakage but incidence of adverse events and serious adverse events were slightly lower in the A-Part Gel(®) group compared to the control. Adhesion rates were comparable in both groups. A-Part Gel(®) is safe as an adhesion prophylaxis after abdominal wall surgery but no reduction of postoperative peritoneal adhesion could be found in comparison to the control group. This may at least in part be due to the small sample size as well as to the incomplete coverage of the incision due to the used application. NCT00646412.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 27%
Researcher 3 27%
Student > Bachelor 2 18%
Student > Doctoral Student 1 9%
Student > Postgraduate 1 9%
Other 0 0%
Unknown 1 9%
Readers by discipline Count As %
Medicine and Dentistry 4 36%
Biochemistry, Genetics and Molecular Biology 2 18%
Chemical Engineering 1 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Materials Science 1 9%
Other 1 9%
Unknown 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2015.
All research outputs
#11,181,504
of 12,566,468 outputs
Outputs from Annals of Surgical Innovation and Research
#19
of 28 outputs
Outputs of similar age
#283,139
of 346,302 outputs
Outputs of similar age from Annals of Surgical Innovation and Research
#4
of 5 outputs
Altmetric has tracked 12,566,468 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 28 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.5. This one scored the same or higher as 9 of them.
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