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Gliotransmission Modulates Baseline Mechanical Nociception

Overview of attention for article published in Molecular Pain, January 2011
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Title
Gliotransmission Modulates Baseline Mechanical Nociception
Published in
Molecular Pain, January 2011
DOI 10.1186/1744-8069-7-93
Pubmed ID
Authors

Jeannine C Foley, Sally R McIver, Philip G Haydon

Abstract

Pain is a physiological and adaptive process which occurs to protect organisms from tissue damage and extended injury. Pain sensation beyond injury, however, is a pathological process which is poorly understood. Experimental models of neuropathic pain demonstrate that reactive astrocytes contribute to reduced nociceptive thresholds. Astrocytes release "gliotransmitters" such as D-serine, glutamate, and ATP, which is extracellularly hydrolyzed to adenosine. Adenosine 1 receptor activation in the spinal cord has anti-nociceptive effects on baseline pain threshold, but the source of the endogenous ligand (adenosine) in the spinal cord is unknown. In this study we used a transgenic mouse model in which SNARE-mediated gliotransmission was selectively attenuated (called dnSNARE mice) to investigate the role of astrocytes in mediating baseline nociception and the development of neuropathic pain. Under baseline conditions, immunostaining in the dorsal horn of the spinal cord showed astrocyte-specific transgene expression in dnSNARE mice, and no difference in expression levels of the astrocyte marker GFAP and the microglia marker Iba1 relative to wild-type mice. The Von Frey filament test was used to probe sensitivity to baseline mechanical pain thresholds and allodynia following the spared nerve injury model of neuropathic pain. DnSNARE mice exhibit a reduced nociceptive threshold in response to mechanical stimulation compared to wild-type mice under baseline conditions, but nociceptive thresholds following spared nerve injury were similar between dnSNARE and wild-types. This study is the first to provide evidence that gliotransmission contributes to basal mechanical nociception.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
France 1 2%
Unknown 56 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 29%
Researcher 9 15%
Professor 6 10%
Professor > Associate Professor 5 8%
Student > Master 5 8%
Other 10 17%
Unknown 7 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 31%
Neuroscience 16 27%
Medicine and Dentistry 10 17%
Psychology 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 3 5%
Unknown 9 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2012.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Molecular Pain
#477
of 669 outputs
Outputs of similar age
#170,829
of 190,479 outputs
Outputs of similar age from Molecular Pain
#29
of 36 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.