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A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

Overview of attention for article published in BMC Genetics, December 2015
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Title
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Published in
BMC Genetics, December 2015
DOI 10.1186/s12863-015-0299-4
Pubmed ID
Authors

Sharon M. Lutz, Michael H. Cho, Kendra Young, Craig P. Hersh, Peter J. Castaldi, Merry-Lynn McDonald, Elizabeth Regan, Manuel Mattheisen, Dawn L. DeMeo, Margaret Parker, Marilyn Foreman, Barry J. Make, Robert L. Jensen, Richard Casaburi, David A. Lomas, Surya P. Bhatt, Per Bakke, Amund Gulsvik, James D. Crapo, Terri H. Beaty, Nan M. Laird, Christoph Lange, John E. Hokanson, Edwin K. Silverman

Abstract

Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (lowest p-value = 2.17 × 10(-11)), and FEV1/FVC was associated with a genomic region on chromosome 4 [upstream of HHIP] (lowest p-value = 5.94 × 10(-10)); both regions have been previously associated with COPD. For the meta-analysis, in addition to confirming associations to the regions near CHRNA3/5 and HHIP, genome-wide significant associations were identified for FEV1 on chromosome 1 [TGFB2] (p-value = 8.99 × 10(-9)), 9 [DBH] (p-value = 9.69 × 10(-9)) and 19 [CYP2A6/7] (p-value = 3.49 × 10(-8)) and for FEV1/FVC on chromosome 1 [TGFB2] (p-value = 8.99 × 10(-9)), 4 [FAM13A] (p-value = 3.88 × 10(-12)), 11 [MMP3/12] (p-value = 3.29 × 10(-10)) and 14 [RIN3] (p-value = 5.64 × 10(-9)). In a large genome-wide association study of lung function in smokers, we found genome-wide significant associations at several previously described loci with lung function or COPD. We additionally identified a novel genome-wide significant locus with FEV1 on chromosome 9 [DBH] in a meta-analysis of three study populations.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 1%
Canada 1 1%
Unknown 84 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 19%
Student > Ph. D. Student 12 14%
Student > Master 8 9%
Student > Doctoral Student 7 8%
Student > Bachelor 7 8%
Other 21 24%
Unknown 15 17%
Readers by discipline Count As %
Medicine and Dentistry 22 26%
Biochemistry, Genetics and Molecular Biology 18 21%
Agricultural and Biological Sciences 13 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Immunology and Microbiology 3 3%
Other 7 8%
Unknown 19 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2015.
All research outputs
#5,670,116
of 6,644,977 outputs
Outputs from BMC Genetics
#523
of 639 outputs
Outputs of similar age
#224,376
of 278,471 outputs
Outputs of similar age from BMC Genetics
#25
of 33 outputs
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So far Altmetric has tracked 639 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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