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Myosin II activity dependent and independent vinculin recruitment to the sites of E-cadherin-mediated cell-cell adhesion

Overview of attention for article published in BMC Molecular and Cell Biology, November 2011
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Title
Myosin II activity dependent and independent vinculin recruitment to the sites of E-cadherin-mediated cell-cell adhesion
Published in
BMC Molecular and Cell Biology, November 2011
DOI 10.1186/1471-2121-12-48
Pubmed ID
Authors

Grant M Sumida, Tyler M Tomita, Wenting Shih, Soichiro Yamada

Abstract

Maintaining proper adhesion between neighboring cells depends on the ability of cells to mechanically respond to tension at cell-cell junctions through the actin cytoskeleton. Thus, identifying the molecules involved in responding to cell tension would provide insight into the maintenance, regulation, and breakdown of cell-cell junctions during various biological processes. Vinculin, an actin-binding protein that associates with the cadherin complex, is recruited to cell-cell contacts under increased tension in a myosin II-dependent manner. However, the precise role of vinculin at force-bearing cell-cell junctions and how myosin II activity alters the recruitment of vinculin at quiescent cell-cell contacts have not been demonstrated.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
France 3 3%
Unknown 86 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 33%
Researcher 24 26%
Student > Master 7 8%
Professor 5 5%
Student > Bachelor 4 4%
Other 11 12%
Unknown 11 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 50%
Biochemistry, Genetics and Molecular Biology 18 20%
Engineering 4 4%
Medicine and Dentistry 3 3%
Physics and Astronomy 3 3%
Other 5 5%
Unknown 13 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2012.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from BMC Molecular and Cell Biology
#1,054
of 1,233 outputs
Outputs of similar age
#141,422
of 153,746 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#24
of 27 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,746 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.