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Freeze–thaw Caenorhabditis elegans freeze–thaw stress response is regulated by the insulin/IGF-1 receptor daf-2

Overview of attention for article published in BMC Genetics, December 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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4 tweeters
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1 Facebook page

Citations

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6 Dimensions

Readers on

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26 Mendeley
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Title
Freeze–thaw Caenorhabditis elegans freeze–thaw stress response is regulated by the insulin/IGF-1 receptor daf-2
Published in
BMC Genetics, December 2015
DOI 10.1186/s12863-015-0298-5
Pubmed ID
Authors

Jian-Ping Hu, Xiao-Ying Xu, Li-Ying Huang, Li-shun Wang, Ning-Yuan Fang

Abstract

Adaption to cold temperatures, especially those below freezing, is essential for animal survival in cold environments. Freezing is also used for many medical, scientific, and industrial purposes. Natural freezing survival in animals has been extensively studied. However, the underlying mechanisms remain unclear. Previous studies demonstrated that animals survive in extremely cold weather by avoiding freezing or controlling the rate of ice-crystal formation in their bodies, which indicates that freezing survival is a passive thermodynamic process. Here, we showed that genetic programming actively promotes freezing survival in Caenorhabditis elegans. We found that daf-2, an insulin/IGF-1 receptor homologue, and loss-of-function enhanced survival during freeze-thaw stress, which required the transcription factor daf-16/FOXO and age-independent target genes. In particular, the freeze-thaw resistance of daf-2(rf) is highly allele-specific and has no correlation with lifespan, dauer formation, or hypoxia stress resistance. Our results reveal a new function for daf-2 signaling, and, most importantly, demonstrate that genetic programming contributes to freezing survival.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 35%
Researcher 5 19%
Student > Bachelor 3 12%
Professor > Associate Professor 2 8%
Professor 1 4%
Other 4 15%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 46%
Biochemistry, Genetics and Molecular Biology 8 31%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Medicine and Dentistry 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2017.
All research outputs
#4,529,088
of 9,693,658 outputs
Outputs from BMC Genetics
#281
of 769 outputs
Outputs of similar age
#117,171
of 310,455 outputs
Outputs of similar age from BMC Genetics
#9
of 36 outputs
Altmetric has tracked 9,693,658 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 769 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,455 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.