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Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening

Overview of attention for article published in Cell & Bioscience, December 2015
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About this Attention Score

  • Among the highest-scoring outputs from this source (#39 of 254)
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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1 tweeter
patent
2 patents

Citations

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7 Dimensions

Readers on

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14 Mendeley
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Title
Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening
Published in
Cell & Bioscience, December 2015
DOI 10.1186/s13578-015-0059-1
Pubmed ID
Authors

Hui Wang, KeHui Liu, Bernard A. M. Fang, HaiQing Wu, FengDi Li, XiaoGang Xiang, WeiLiang Tang, GangDe Zhao, LanYi Lin, Shisan Bao, Qing Xie

Abstract

The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei. The regulatory mechanism of HBV replication by acetyltransferase is thus far not well understood, but human acetyltransferase has been reported as being involved in the regulation of HBV replication. Depletion of KAT8 or HAT1 via RNA interference (RNAi) markedly down-regulated HBV-DNA and pgRNA levels in HepG2.2.15 cells, with KAT8 knockdown reducing both HBsAg and HBeAg more than HAT1 knockdown. Consistent with these observations, HBV replication regulators hepatocyte nuclear factor-4-α (HNF4α) and peroxisome proliferator-activated receptor gamma coactivator- (PPARGC-) 1-α were decreased following knockdown of HAT1 or KAT8. These data suggest that KAT8 or HAT1 regulate HBV replication and may be potential drug targets of anti-HBV therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 21%
Student > Ph. D. Student 3 21%
Student > Bachelor 2 14%
Other 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 3 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 43%
Biochemistry, Genetics and Molecular Biology 3 21%
Nursing and Health Professions 1 7%
Medicine and Dentistry 1 7%
Unknown 3 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2017.
All research outputs
#3,312,475
of 12,330,736 outputs
Outputs from Cell & Bioscience
#39
of 254 outputs
Outputs of similar age
#88,025
of 326,767 outputs
Outputs of similar age from Cell & Bioscience
#4
of 31 outputs
Altmetric has tracked 12,330,736 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 254 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,767 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.