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Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening

Overview of attention for article published in Cell & Bioscience, December 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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1 X user
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3 patents

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19 Mendeley
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Title
Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening
Published in
Cell & Bioscience, December 2015
DOI 10.1186/s13578-015-0059-1
Pubmed ID
Authors

Hui Wang, KeHui Liu, Bernard A. M. Fang, HaiQing Wu, FengDi Li, XiaoGang Xiang, WeiLiang Tang, GangDe Zhao, LanYi Lin, Shisan Bao, Qing Xie

Abstract

The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei. The regulatory mechanism of HBV replication by acetyltransferase is thus far not well understood, but human acetyltransferase has been reported as being involved in the regulation of HBV replication. Depletion of KAT8 or HAT1 via RNA interference (RNAi) markedly down-regulated HBV-DNA and pgRNA levels in HepG2.2.15 cells, with KAT8 knockdown reducing both HBsAg and HBeAg more than HAT1 knockdown. Consistent with these observations, HBV replication regulators hepatocyte nuclear factor-4-α (HNF4α) and peroxisome proliferator-activated receptor gamma coactivator- (PPARGC-) 1-α were decreased following knockdown of HAT1 or KAT8. These data suggest that KAT8 or HAT1 regulate HBV replication and may be potential drug targets of anti-HBV therapy.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 21%
Researcher 3 16%
Student > Ph. D. Student 3 16%
Unspecified 1 5%
Other 1 5%
Other 2 11%
Unknown 5 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 32%
Biochemistry, Genetics and Molecular Biology 5 26%
Medicine and Dentistry 2 11%
Nursing and Health Professions 1 5%
Unspecified 1 5%
Other 0 0%
Unknown 4 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2023.
All research outputs
#4,941,334
of 24,293,076 outputs
Outputs from Cell & Bioscience
#127
of 1,077 outputs
Outputs of similar age
#79,265
of 396,339 outputs
Outputs of similar age from Cell & Bioscience
#1
of 17 outputs
Altmetric has tracked 24,293,076 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,077 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,339 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.