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Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review

Overview of attention for article published in Eye and Vision, September 2018
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Title
Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review
Published in
Eye and Vision, September 2018
DOI 10.1186/s40662-018-0118-x
Pubmed ID
Authors

Malvika Arya, Almyr S. Sabrosa, Jay S. Duker, Nadia K. Waheed

Abstract

Age-related macular degeneration (AMD) is a leading cause of central vision loss worldwide. The progression of dry AMD from early to intermediate stages is primarily characterized by increasing drusen formation and adverse impact on outer retinal cells. Late stage AMD consists of either geographic atrophy (GA), the non-exudative (dry) AMD subtype, or choroidal neovascularization, the exudative (wet) AMD subtype. GA is characterized by outer retinal and choroidal atrophy, specifically the photoreceptor layer, RPE, and choriocapillaris. Much remains to be discovered regarding the pathogenesis of AMD progression and subsequent development of GA. As the functionality of all three layers is closely linked, the temporal sequence of events that end up in atrophy is important in the understanding of the pathogenic pathway of the disease. The advent of OCTA, and particularly of swept-source technology, has allowed for depth-resolved imaging of retinal vasculature and the choriocapillaris. With the use of OCTA, recent studies demonstrate that choriocapillaris flow alterations are closely associated with the development and progression of AMD. Such changes may even possibly offer predictive value in determining progression of GA. This article reviews studies demonstrating choriocapillaris changes in dry AMD and summarizes the existing literature on the potential role of the choriocapillaris as a key factor in the pathogenesis of AMD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 105 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 12%
Student > Bachelor 10 10%
Student > Master 10 10%
Student > Ph. D. Student 10 10%
Student > Doctoral Student 9 9%
Other 16 15%
Unknown 37 35%
Readers by discipline Count As %
Medicine and Dentistry 30 29%
Biochemistry, Genetics and Molecular Biology 10 10%
Engineering 6 6%
Neuroscience 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 8 8%
Unknown 44 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2018.
All research outputs
#20,533,292
of 23,103,436 outputs
Outputs from Eye and Vision
#121
of 243 outputs
Outputs of similar age
#294,089
of 337,900 outputs
Outputs of similar age from Eye and Vision
#7
of 9 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 243 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.