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The piRNA pathway responds to environmental signals to establish intergenerational adaptation to stress

Overview of attention for article published in BMC Biology, September 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

twitter
13 tweeters

Citations

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36 Dimensions

Readers on

mendeley
61 Mendeley
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Title
The piRNA pathway responds to environmental signals to establish intergenerational adaptation to stress
Published in
BMC Biology, September 2018
DOI 10.1186/s12915-018-0571-y
Pubmed ID
Authors

Tony Belicard, Pree Jareosettasin, Peter Sarkies

Abstract

piRNAs have a constitutive role in genome defence by silencing transposable elements in the germline. In the nematode Caenorhabditis elegans, piRNAs also induce epigenetic silencing of transgenes, which can be maintained for many generations in the absence of the piRNA pathway. The role of multi-generational epigenetic inheritance in adaptation to the environment is unknown. Here, we show that piRNA biogenesis is downregulated in response to a small increase in temperature. Some effects on gene expression persist into subsequent generations and are associated with a negative fitness cost. We show that simultaneous infection with pathogenic bacteria suppresses downregulation of the piRNA pathway in response to increased temperature. This effect is associated with increased fitness of progeny of infected animals in subsequent generations. Our results show that the piRNA pathway integrates inputs from the environment to establish intergenerational responses to environmental conditions, with important consequences for the fitness of the subsequent generation.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 33%
Researcher 9 15%
Student > Bachelor 7 11%
Student > Doctoral Student 5 8%
Professor 3 5%
Other 7 11%
Unknown 10 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 44%
Agricultural and Biological Sciences 17 28%
Medicine and Dentistry 2 3%
Neuroscience 2 3%
Social Sciences 1 2%
Other 3 5%
Unknown 9 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2018.
All research outputs
#4,246,394
of 17,370,809 outputs
Outputs from BMC Biology
#886
of 1,500 outputs
Outputs of similar age
#83,733
of 285,113 outputs
Outputs of similar age from BMC Biology
#1
of 1 outputs
Altmetric has tracked 17,370,809 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,500 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,113 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them