Title |
Refractory septic shock: our pragmatic approach
|
---|---|
Published in |
Critical Care, September 2018
|
DOI | 10.1186/s13054-018-2144-4 |
Pubmed ID | |
Authors |
Prashanth Nandhabalan, Nicholas Ioannou, Christopher Meadows, Duncan Wyncoll |
Abstract |
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such patients are often poorly represented in large clinical trials. Consequently, good evidence for effective treatment strategies is lacking. In this article, we describe a pragmatic, multi-faceted approach to managing patients with refractory septic shock based on our experience of toxin-mediated sepsis in a specialist referral centre. Many components of this strategy are inexpensive and widely accessible, and so may offer an opportunity to improve outcomes in these critically ill patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 32 | 21% |
United States | 12 | 8% |
Colombia | 11 | 7% |
Spain | 7 | 5% |
Mexico | 7 | 5% |
Ecuador | 5 | 3% |
Canada | 3 | 2% |
Malaysia | 2 | 1% |
Australia | 2 | 1% |
Other | 25 | 16% |
Unknown | 46 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 111 | 73% |
Practitioners (doctors, other healthcare professionals) | 25 | 16% |
Scientists | 11 | 7% |
Science communicators (journalists, bloggers, editors) | 5 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 207 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 37 | 18% |
Student > Postgraduate | 29 | 14% |
Student > Master | 19 | 9% |
Researcher | 18 | 9% |
Student > Ph. D. Student | 12 | 6% |
Other | 52 | 25% |
Unknown | 40 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 131 | 63% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Neuroscience | 3 | 1% |
Nursing and Health Professions | 3 | 1% |
Social Sciences | 3 | 1% |
Other | 10 | 5% |
Unknown | 50 | 24% |