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Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study

Overview of attention for article published in BMC Psychiatry, September 2018
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3 tweeters
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1 Facebook page

Citations

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11 Dimensions

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Title
Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study
Published in
BMC Psychiatry, September 2018
DOI 10.1186/s12888-018-1849-x
Pubmed ID
Authors

Xi Xia, Mei Ding, Jin-feng Xuan, Jia-xin Xing, Hao Pang, Bao-jie Wang, Jun Yao

Abstract

Schizophrenia is associated with multiple neurotransmitter disorders, including serotonin (5-hydroxytryptamine, 5-HT). The neuromodulatory action of serotonin on brain function largely depends on the action of specific subtypes of serotonin receptors. The serotonin receptor 1B (HTR1B) gene has been proposed to play putative roles in the development of multiple emotional and psychiatric disorders. To study the relationship of HTR1B polymorphisms and schizophrenia, gene information was drawn from a cohort of 310 schizophrenic patients (152 men and 158 women) and 313 healthy controls (153 men and 160 women) of northern Han Chinese descent. The χ2 test was used to compare allele and genotype distributions between case and control groups. The haplotype and linkage equilibrium were also assessed in two group comparisons. We detected 14 SNPs. Male patients were observed to have higher frequencies of the A-allele and AA+AG genotype at rs1778258 than female patients (p = 0.012 and p = 0.015, respectively). Both the A-allele and AA+AG genotype were associated with schizophrenia risk (OR = 1.986 and OR = 2.061, respectively), although the statistical significance of the genotype was lost after Bonferroni correction. Linkage analysis showed that rs17273700, rs11568817, rs9361234 and rs58138557 polymorphisms exhibit strong linkage disequilibrium (LD). In addition, schizophrenic patients show stronger linkage between 11,568,817 and rs130058 than healthy controls. HTR1B polymorphisms are associated with schizophrenia in the northern Han Chinese population, which provides an etiological reference for schizophrenia.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Researcher 3 11%
Student > Bachelor 3 11%
Student > Ph. D. Student 3 11%
Unspecified 2 7%
Other 5 19%
Unknown 6 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 26%
Medicine and Dentistry 3 11%
Psychology 3 11%
Unspecified 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 0 0%
Unknown 11 41%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2018.
All research outputs
#8,828,545
of 14,591,133 outputs
Outputs from BMC Psychiatry
#2,231
of 3,276 outputs
Outputs of similar age
#154,018
of 273,869 outputs
Outputs of similar age from BMC Psychiatry
#1
of 1 outputs
Altmetric has tracked 14,591,133 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,276 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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