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Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice

Overview of attention for article published in Molecular Brain, September 2018
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Title
Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
Published in
Molecular Brain, September 2018
DOI 10.1186/s13041-018-0396-1
Pubmed ID
Authors

Shuang Qiu, Yu Wu, Xinyou Lv, Xia Li, Min Zhuo, Kohei Koga

Abstract

Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little is known about the changes of synaptic KAR in the cortical area of Fmr1 KO mice. In this study, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons in the insular cortex of Fmr1 KO mice. We found that KARs mediated currents were reduced in Fmr1 KO mice. KARs were mainly located in the synaptosomal fraction of the insular cortex. The abundance of KAR subunit GluK1 and GluK2/3 in the synaptosome was reduced in Fmr1 KO mice, whereas the total expressions of these KARs subunits were not changed. Finally, lack of FMRP impairs subsequent internalization of surface GluK2 after KAR activation, while having no effect on the surface GluK2 expression. Our studies provide evidence indicating that loss of FMRP leads to the abnormal function and localization of KARs. This finding implies a new molecular mechanism for Fragile X syndrome.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 23%
Researcher 2 15%
Student > Postgraduate 2 15%
Student > Ph. D. Student 2 15%
Professor 1 8%
Other 2 15%
Unknown 1 8%
Readers by discipline Count As %
Neuroscience 5 38%
Psychology 2 15%
Veterinary Science and Veterinary Medicine 1 8%
Medicine and Dentistry 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 1 8%
Unknown 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#10,369,042
of 13,589,098 outputs
Outputs from Molecular Brain
#410
of 623 outputs
Outputs of similar age
#184,923
of 265,636 outputs
Outputs of similar age from Molecular Brain
#1
of 1 outputs
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