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Reduced IL-33 plasma levels in aplastic anemia

Overview of attention for article published in Cancer Cell International, December 2015
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Title
Reduced IL-33 plasma levels in aplastic anemia
Published in
Cancer Cell International, December 2015
DOI 10.1186/s12935-015-0270-5
Pubmed ID
Authors

Ming Sun, Hai-feng Ma, Ye-yun Che, Xin Cui

Abstract

In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA). Plasma IL-33, IL-17 and sST2 levels were measured in patients with active AA (n = 31), AA in remission (n = 29) and in healthy subjects (n = 30), using enzyme linked immunosorbent assays (ELISAs). The results showed that sST2 and IL-17 levels were significantly elevated in patients with active AA when compared to control subjects, but IL-33 levels were significantly lower in AA patients, which resulted in elevated sST2/IL-33 ratios in patients with active disease. During remission stages, the levels of these cytokines were comparable to those of healthy controls. The elevated levels of sST2/IL-33 in the plasma during active stages of the disease suggest a possible role in the pathogenesis and course of AA.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 33%
Student > Bachelor 2 22%
Student > Master 2 22%
Student > Ph. D. Student 1 11%
Researcher 1 11%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 3 33%
Agricultural and Biological Sciences 2 22%
Immunology and Microbiology 2 22%
Biochemistry, Genetics and Molecular Biology 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#5,807,093
of 6,790,336 outputs
Outputs from Cancer Cell International
#227
of 287 outputs
Outputs of similar age
#232,810
of 288,037 outputs
Outputs of similar age from Cancer Cell International
#19
of 33 outputs
Altmetric has tracked 6,790,336 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 287 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.