Title |
Reduced IL-33 plasma levels in aplastic anemia
|
---|---|
Published in |
Cancer Cell International, December 2015
|
DOI | 10.1186/s12935-015-0270-5 |
Pubmed ID | |
Authors |
Ming Sun, Hai-feng Ma, Ye-yun Che, Xin Cui |
Abstract |
In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA). Plasma IL-33, IL-17 and sST2 levels were measured in patients with active AA (n = 31), AA in remission (n = 29) and in healthy subjects (n = 30), using enzyme linked immunosorbent assays (ELISAs). The results showed that sST2 and IL-17 levels were significantly elevated in patients with active AA when compared to control subjects, but IL-33 levels were significantly lower in AA patients, which resulted in elevated sST2/IL-33 ratios in patients with active disease. During remission stages, the levels of these cytokines were comparable to those of healthy controls. The elevated levels of sST2/IL-33 in the plasma during active stages of the disease suggest a possible role in the pathogenesis and course of AA. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 33% |
Student > Bachelor | 2 | 22% |
Student > Master | 2 | 22% |
Student > Ph. D. Student | 1 | 11% |
Researcher | 1 | 11% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 33% |
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Immunology and Microbiology | 2 | 22% |
Agricultural and Biological Sciences | 2 | 22% |