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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intradermal injection of human adipose-derived stem cells accelerates skin wound healing in nude mice
|
|---|---|
| Published in |
Stem Cell Research & Therapy, December 2015
|
| DOI | 10.1186/s13287-015-0238-3 |
| Pubmed ID | |
| Authors |
Jonathan Rodriguez, Fabien Boucher, Charlotte Lequeux, Audrey Josset-Lamaugarny, Ondine Rouyer, Orianne Ardisson, Héléna Rutschi, Dominique Sigaudo-Roussel, Odile Damour, Ali Mojallal |
| Abstract |
The use of stem cells from adipose tissue or adipose-derived stem cells (ASCs) in regenerative medicine could be an interesting alternative to bone marrow stem cells because they are easily accessible and available in large quantities. The aim of this study was to evaluate the potential effect of ASCs on the healing of 12 mm diameter-excisional wounds (around 110 mm(2)) in nude mice. Thirty nude mice underwent surgery to create one 12-mm excisional wound per mouse (spontaneous healing, n = 6; Cytocare® 532, n = 12; ASCs, n = 12). The Galiano wound model was chosen to avoid shrinkage and thus slow the spontaneous healing (SH) of mouse skin, making it closer to the physiology of human skin healing. Transparent dressings were used to enable daily healing time measurements to be taken. Immunohistochemistry, histological and blood perfusion analysis were carried out on the healed skin. The in vivo results showed the effectiveness of using ASCs on reducing the time needed for complete healing to 21.2 days for SH, 17.4 days for vehicle alone (Cytocare® 532) and 14.6 days with the addition of ASCs (p < 0.001). Moreover, cutaneous perfusion of the healed wound was significantly improved in ASC-treated mice compared to SH group, as shown by laser Doppler flowmetry and the quantitation of blood vessels using immunohistochemistry of αsmooth muscle actin. The tolerance and efficacy of cryopreserved ASCs to accelerate the complete closure of the wound by increasing the maturation of the skin and its blood perfusion, shows their therapeutic benefit in the wound healing context. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 68 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 17% |
| Student > Master | 11 | 16% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Doctoral Student | 6 | 9% |
| Student > Bachelor | 4 | 6% |
| Other | 14 | 20% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 39% |
| Agricultural and Biological Sciences | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Engineering | 4 | 6% |
| Nursing and Health Professions | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 17 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2015.
All research outputs
#17,778,896
of 22,835,198 outputs
Outputs from Stem Cell Research & Therapy
#1,588
of 2,420 outputs
Outputs of similar age
#264,222
of 388,733 outputs
Outputs of similar age from Stem Cell Research & Therapy
#45
of 56 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,420 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 388,733 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.