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Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs

Overview of attention for article published in BMC Veterinary Research, September 2018
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Title
Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs
Published in
BMC Veterinary Research, September 2018
DOI 10.1186/s12917-018-1617-7
Pubmed ID
Authors

Hyuck-Joo Yang, Ye-In Oh, Jong-Woo Jeong, Kun-Ho Song, Tae-Sung Koo, Kyoung-Won Seo

Abstract

Sildenafil citrate, a highly selective phosphodiesterase type 5 inhibitor, is used to treat pulmonary hypertension (PH) in veterinary medicine. The objective of this study was to investigate pharmacokinetic profiles by oral administration of orally disintegrating film (ODF) and film coated tablet (FCT) formulations and rectal administration of ODF formulation in healthy dogs. Twelve healthy beagle dogs were administered four separate doses of sildenafil: FCT formulation 2 mg/kg orally, ODF formulation 2 mg/kg orally, ODF formulation 2 mg/kg rectally, and ODF formulation 10 mg/kg rectally. For 24 hours following administration, blood samples were collected and the plasma concentrations of sildenafil were assayed by liquid chromatography-tandem mass spectrometry. There were no significant differences in all the pharmacokinetic parameters between FCT and ODF formulations when administrated orally. Cmax at the time of rectal administration was lower when the same dose was given as that orally administered. No serious systemic adverse events (AEs) were observed. These findings suggest that sildenafil ODF formulation can be used as an alternative to FCT formulation in the treatment of canine PH patients; additionally, rectal administration of sildenafil ODF may be a beneficial treatment option for canine patients who are unable to receive medication orally.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Other 3 15%
Student > Master 2 10%
Student > Ph. D. Student 1 5%
Unknown 10 50%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 30%
Medicine and Dentistry 2 10%
Unknown 12 60%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2018.
All research outputs
#17,990,409
of 23,103,903 outputs
Outputs from BMC Veterinary Research
#1,703
of 3,084 outputs
Outputs of similar age
#243,613
of 340,828 outputs
Outputs of similar age from BMC Veterinary Research
#46
of 80 outputs
Altmetric has tracked 23,103,903 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,084 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.