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Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

Overview of attention for article published in BMC Cancer, December 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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Title
Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway
Published in
BMC Cancer, December 2015
DOI 10.1186/s12885-015-1965-7
Pubmed ID
Authors

Chia-Hung Lin, Ching-Yao Chang, Kuan-Rong Lee, Hui-Ju Lin, Ter-Hsin Chen, Lei Wan

Abstract

Flavones found in plants display various biological activities, including anti-allergic, anti-viral, anti-inflammatory, anti-oxidation, and anti-tumor effects. In this study, we investigated the anti-tumor effects of flavone, apigenin and luteolin on human breast cancer cells. The anti-cancer activity of flavone, apigenin and luteolin was investigated using the MTS assay. Apoptosis was analyzed by Hoechst 33342 staining, flow cytometry and western blot. Cell migration was determined using the culture inserts and xCELLigence real-time cell analyzer instrument equipped with a CIM-plate 16. Real-time quantitative PCR and western blot were used to determine the signaling pathway elicited by flavone, apigenin and luteolin. Flavone, apigenin and luteolin showed potent inhibitory effects on the proliferation of Hs578T, MDA-MB-231 and MCF-7 breast cancer cells in a concentration and time-dependent manner. The ability of flavone, apigenin and luteolin to inhibit the growth of breast cancer cells through apoptosis was confirmed by Hoechst33342 staining and the induction of sub-G1 phase of the cell cycle. Flavone, apigenin and luteolin induced forkhead box O3 (FOXO3a) expression by inhibiting Phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB)/Akt. This subsequently elevated the expression of FOXO3a target genes, including the Cyclin-dependent kinase inhibitors p21(Cip1) (p21) and p27(kip1) (p27), which increased the levels of activated poly(ADP) polymerase (PARP) and cytochrome c. Taken together, these data demonstrated that flavone, apigenin and luteolin induced cell cycle arrest and apoptosis in breast cancer cells through inhibiting PI3K/Akt activation and increasing FOXO3a activation, which suggest that flavone, apigenin and luteolin will be the potential leads for the preventing and treating of breast cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Croatia 2 2%
United States 1 1%
Unknown 94 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 14%
Student > Master 14 14%
Researcher 12 12%
Student > Bachelor 10 10%
Student > Doctoral Student 7 7%
Other 16 16%
Unknown 24 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 21%
Pharmacology, Toxicology and Pharmaceutical Science 15 15%
Agricultural and Biological Sciences 12 12%
Chemistry 6 6%
Medicine and Dentistry 5 5%
Other 12 12%
Unknown 27 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2016.
All research outputs
#3,946,744
of 22,835,198 outputs
Outputs from BMC Cancer
#934
of 8,307 outputs
Outputs of similar age
#66,595
of 390,452 outputs
Outputs of similar age from BMC Cancer
#17
of 187 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,307 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 390,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 187 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.