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Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study

Overview of attention for article published in BMC Infectious Diseases, September 2018
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1 tweeter

Citations

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3 Dimensions

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22 Mendeley
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Title
Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study
Published in
BMC Infectious Diseases, September 2018
DOI 10.1186/s12879-018-3399-8
Pubmed ID
Authors

Chris Kenyon, Kara Krista Osbak, Tania Crucitti, Luc Kestens

Abstract

Ascertaining if the clinical and immunological response to repeat syphilis differs from that in initial syphilis may assist in designing optimal syphilis screening strategies and vaccine design. We prospectively recruited 120 patients with a new diagnosis of (baseline) syphilis. During a 24-month follow-up period, 11 of these patients had a further diagnosis of (repeat) syphilis. We conducted a paired comparison of their plasma cyto-chemokines at baseline and repeat syphilis. Comparing to their baseline infection, paired analyses of the 11 individuals with repeat infections during follow-up revealed that these reinfections had lower concentrations of Interferon (IFN)α (0.8 [Interquartile range (IQR) 0.8-0.8 vs. 12.2 [IQR 1.6-24.2], P = 0.004) and Chemokine (C-C motif) ligand (CCL) 4 (0.9 [IQR 0.9-12.2 vs. 17.5 [IQR 4.9-32.8], P = 0.022]. In this small study of 11 individuals, repeat syphilis was found to present with an attenuated immune response. The relevance of these findings to the design of optimal syphilis screening programs is discussed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 32%
Other 3 14%
Student > Doctoral Student 3 14%
Researcher 2 9%
Student > Ph. D. Student 2 9%
Other 4 18%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 6 27%
Immunology and Microbiology 3 14%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 2 9%
Nursing and Health Professions 1 5%
Other 3 14%
Unknown 4 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2018.
All research outputs
#8,510,539
of 13,560,184 outputs
Outputs from BMC Infectious Diseases
#2,775
of 5,057 outputs
Outputs of similar age
#159,813
of 265,003 outputs
Outputs of similar age from BMC Infectious Diseases
#1
of 1 outputs
Altmetric has tracked 13,560,184 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,057 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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