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Severe brain atrophy after long-term survival seen in siblings with familial amyotrophic lateral sclerosis and a mutation in the optineurin gene: a case series

Overview of attention for article published in Journal of Medical Case Reports, December 2011
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Title
Severe brain atrophy after long-term survival seen in siblings with familial amyotrophic lateral sclerosis and a mutation in the optineurin gene: a case series
Published in
Journal of Medical Case Reports, December 2011
DOI 10.1186/1752-1947-5-573
Pubmed ID
Authors

Hiroki Ueno, Keitaro Kobatake, Masayasu Matsumoto, Hiroyuki Morino, Hirofumi Maruyama, Hideshi Kawakami

Abstract

Previous studies have shown widespread multisystem degeneration in patients with sporadic amyotrophic lateral sclerosis who develop a total locked-in state and survive under mechanical ventilation for a prolonged period of time. However, the disease progressions reported in these studies were several years after disease onset. There have been no reports of long-term follow-up with brain imaging of patients with familial amyotrophic lateral sclerosis at an advanced stage of the disease. We report the cases of siblings with amyotrophic lateral sclerosis with homozygous deletions of the exon 5 mutation of the gene encoding optineurin, in whom brain computed tomography scans were followed up for more than 20 years.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Student > Doctoral Student 5 19%
Student > Master 4 15%
Professor 2 7%
Student > Ph. D. Student 2 7%
Other 5 19%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 10 37%
Neuroscience 6 22%
Agricultural and Biological Sciences 3 11%
Biochemistry, Genetics and Molecular Biology 2 7%
Physics and Astronomy 1 4%
Other 1 4%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2011.
All research outputs
#20,152,153
of 22,659,164 outputs
Outputs from Journal of Medical Case Reports
#3,444
of 3,875 outputs
Outputs of similar age
#220,045
of 242,260 outputs
Outputs of similar age from Journal of Medical Case Reports
#43
of 54 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,875 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.