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Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases

Overview of attention for article published in Stem Cell Research & Therapy, September 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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6 X users
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1 Google+ user

Citations

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Readers on

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40 Mendeley
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1 CiteULike
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Title
Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases
Published in
Stem Cell Research & Therapy, September 2018
DOI 10.1186/s13287-018-0986-y
Pubmed ID
Authors

Giuliana Di Rocco, Silvia Baldari, Antonietta Gentile, Maurizio Capogrossi, Gabriele Toietta

Abstract

Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endoplasmic reticulum (ER) is an organelle involved in protein folding, calcium homeostasis, and lipid biosynthesis. Protein disulfide isomerase (PDI) is a molecular chaperone induced and activated by ER stress. PDI is induced by hypoxia in neuronal, cardiac, and endothelial cells, supporting increased cell survival to hypoxic stress and protection from apoptosis in response to ischemia. We achieved ex vivo PDI gene transfer into luciferase-expressing myoblasts and endothelial cells. We assessed cell engraftment upon intramuscular transplantation into a mouse model of Duchenne muscular dystrophy (mdx mouse) and into a mouse model of ischemic disease. We observed that loss of full-length dystrophin expression in mdx mice muscle leads to an increase of PDI expression, possibly in response to augmented ER protein folding load. Moreover, we determined that overexpression of PDI confers a survival advantage for muscle cells in vitro and in vivo to human myoblasts injected into murine dystrophic muscle and to endothelial cells administered upon hindlimb ischemia damage, improving the therapeutic outcome of the cell therapy treatment. Collectively, these results suggest that overexpression of PDI may protect transplanted cells from hypoxia and other possibly occurring ER stresses, and consequently enhance their regenerative properties.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Bachelor 7 18%
Other 3 8%
Student > Master 3 8%
Student > Doctoral Student 1 3%
Other 1 3%
Unknown 18 45%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 23%
Medicine and Dentistry 4 10%
Agricultural and Biological Sciences 2 5%
Mathematics 1 3%
Nursing and Health Professions 1 3%
Other 4 10%
Unknown 19 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2018.
All research outputs
#7,062,623
of 23,105,443 outputs
Outputs from Stem Cell Research & Therapy
#689
of 2,439 outputs
Outputs of similar age
#125,359
of 341,556 outputs
Outputs of similar age from Stem Cell Research & Therapy
#24
of 64 outputs
Altmetric has tracked 23,105,443 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,439 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,556 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.